Reconstruction of Brain Functional Connectivity Underlying Post-Thrombolysis Cognitive Impairment: Insights from Phase Lag Index Analysis

Corresponding author: zhuhengya, zhuhengyaa@163.com

DOI: 10.12201/bmr.202508.00017

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  Abstract: Objective?To investigate the neural mechanisms and clinical utility of the Phase Lag Index (PLI) for assessing cognitive impairment in post-thrombolysis stroke patients, and to identify early electrophysiological biomarkers of post-stroke cognitive dysfunction. Methods?Seventy acute ischemic stroke patients treated with intravenous rt-PA were enrolled and divided by cognitive status into a post-stroke cognitive impairment non-dementia group (PSCIND, n = 37) and a post-stroke dementia group (PSD, n = 33) based on MoCA and MMSE scores. Resting-state EEG was recorded and PLI was computed across four frequency bands (α, β, θ, δ) using EEGLab. Between-group differences in band- and region-specific PLI were compared, and correlations between PLI metrics and cognitive scores were analyzed. Results?Compared with the PSCIND group, the PSD group showed a significant reduction in frontal α-band PLI (P < 0.01), increased β-band connectivity in the frontal region, and marked decreases in frontal-parietal and parietal-occipital network strength (P < 0.05). Conclusion?PLI sensitively captures frequency-specific functional reorganization in post-thrombolysis stroke patients. In particular, α/β-band connectivity patterns hold promise as early electrophysiological markers of post-stroke dementia.

  Key words: Phase Lag Index; Post-thrombolysis Cognitive Impairment; Ischemic Stroke; Brain Functional Connectivity

  Submit time: 7 August 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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