The Role of Inflammation-Mediated Endothelial Dysfunction and Blood-Brain Barrier Disruption in Cerebral Microbleeds

Corresponding author: Han Jianhong, hongjh8@126.com

DOI: 10.12201/bmr.202504.00045

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  Abstract: Cerebral microbleeds are a typical imaging manifestation of cerebral small vessel disease, characterized by the deposition of hemosiderin resulting from damage to small cerebral vessels. They have been confirmed to be significantly associated with cognitive dysfunction, intracerebral hemorrhage events, recurrence of ischemic stroke, and hemorrhagic transformation. However, due to unclear pathogenic mechanisms, there is still a lack of effective early intervention and treatment options in clinical practice. Recent studies have suggested that inflammatory responses, endothelial dysfunction, and increased blood-brain barrier permeability may collaboratively participate in the pathological development of cerebral microbleeds, providing new research directions for targeted intervention and treatment of the disease. This article reviews the role of inflammatory response-mediated endothelial dysfunction and blood-brain barrier damage in the pathogenesis of cerebral microbleeds, along with relevant clinical research evidence, in order to provide reference for the diagnosis and treatment of cerebral microbleeds.

  Key words: Cerebral microbleeds; Inflammatory response; Blood-brain barrier; Endothelial function

  Submit time: 16 April 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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