Plasma C1q/ tumor necrosis factor-associated protein 6 and systemic inflammatory response index levels in patients with heart failure and their clinical significance

Corresponding author: wang zhong, 2775512142@qq.com

DOI: 10.12201/bmr.202501.00060

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  Abstract: Objective To investigate the plasma levels of C1q/ tumor necrosis factor-associated protein 6(CTRP6) and systemic inflammatory response index (SIRI) in patients with heart failure (HF) and their clinical significance. Methods 126 HF patients admitted to the Heart Center of the First Affiliated Hospital of Shihezi University from October 2023 to September 2024 were selected and divided into HFrEF group (n=43), HFmrEF group (n=45) and HFpEF group (n=38) according to LVEF value. And 38 non-HF patients treated in the same period were used as control group. Blood routine, NT-proBNP and echocardiogram parameters were collected, SIRI and left ventricular mass index (IVMI) were calculated, plasma CTRP6 levels were detected by enzyme-linked immunosorbent assay, and the correlation between CTRP6, SIRI and LVEF, IVMI, NT-proBNP and NYHA grades in HF patients was analyzed. Risk factors of HF were analyzed by logistic regression analysis and ROC curve was drawn. Results Compared with the control group, the levels of Cr, UA, eGFR and SIRI in HF patients were increased, the proportion of patients with history of coronary heart disease and atrial fibrillation was increased, and CTRP6 level was decreased, the difference was statistically significant (P < 0.05). There were statistical differences in CTRP6, NT-proBNP, LVEF and IVMI of patients with different ejection fraction classification (P < 0.05). Spearman correlation analysis showed that CTRP6 level was positively correlated with LVEF and negatively correlated with LVMI in HF patients. SIRI was positively correlated with NT-proBNP and negatively correlated with LVEF. Multivariate regression analysis showed that lower CTRP6, higher Cr and history of atrial fibrillation were risk factors for different ejection fraction types of heart failure. The area under ROC curve of CTRP6, SIRI and their combined diagnosis HF are 0.762, 0.772 and 0.850, respectively. Conclusion The plasma CTRP6 level in HF patients is significantly decreased, and SIRI is significantly increased. Both of them have diagnostic value for HF patients, and their combined detection can improve the diagnostic efficiency. CTRP6 decreases with the severity of heart failure and may be a novel biomarker for HF.

  Key words: Complement C1q/tumor necrosis factor-related protein 6; Systemic inflammation response index; Heart failure; Left ventricle remodel; Left ventricular ejection fraction; Left ventricular mass index

  Submit time: 21 January 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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