Correlation between Modic changes of lumbosacral vertebrae and hip bone mineral density in patients with low back pain

DOI: 10.12201/bmr.202502.00046

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  Abstract: Objective Study the Modic changes(MCs)in the lumbar and sacral spine of patients with low back pain and their relationship with osteoporosis. Methods The study included 204 women aged 40-70 years with lumbar pain as the main symptom. The researchers collected data on age, MCs subtype, hip BMD values and T-scores. The patients were divided into two groups based on the presence or absence of MCs in the lumbar spine: the MCs group (139 patients, 68.14%) and the non-MCs group (65 patients, 31.86%). The MCs group was further divided into three subgroups based on MCs subtype: Group type Ⅰ (33 patients), Group type Ⅱ (90 patients), and Group type Ⅲ (16 patients). The researchers conducted a comparative analysis of age, hip BMD values and T-scores between the MCs group and the non-MCs group, and between the three subgroups of the MCs group and the non-MCs group. Results In the group with MCs and the group without MCs, there was no significant difference in age, hip BMD value, and corresponding T value (P>0.05). The Kruskal-Wallis test showed no significant difference in age among the four groups (P>0.05). The data of hip BMD value and T value in all four groups were normally distributed, and the mean values were ranked in the order of type Ⅲ group >non-MCs group > type Ⅱ group >type Ⅰ group. The type Ⅲ group was mostly at the normal level of bone mass, while the remaining three groups were mostly at the level of reduced bone mass and osteoporosis. The LSD method was used for multiple comparisons of hip BMD value and T value parameters (P<0.05). The results showed that the difference in bone mass between the type Ⅱ group and the non-MCs group was not statistically significant (P>0.05),and the differences in bone mass between the type Ⅰ group and the remaining three groups, between the type Ⅱ group and the type Ⅲ group, and between the type Ⅲ group and the non-MCs group were all statistically significant(P<0.05). Conclusion Different bone mass levels have corresponding types of MCs: higher bone mass (normal bone mass) often leads to type Ⅲ MCs, while osteopenia or osteoporosis is prone to type Ⅰ MCs, and the bone mass level of type Ⅱ MCs is mostly matched with the same age group.. It is suggested that patients with low back pain with type Ⅰ of MCs should be payed attention to anti-osteoporosis treatment.

  Key words: low back pain; endplateitis; modic changes; bone mineral density

  Submit time: 24 February 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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