The correlation between serum MHR, NLR, and PLR with essential hypertension

Corresponding author: ZHAO Xingsheng, zhaoxs1121@163.com

DOI: 10.12201/bmr.202411.00052

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  Abstract: ［Abstract］ Objective To investigate whether the ratio of monocyte to high-density lipoprotein cholesterol , neutrophil to lymphocyte, and platelet count to lymphocyte can predict the risk of disease in patients with essential hypertension. A total of 120 essential hypertension patients admitted to the People's Hospital of Inner Mongolia Autonomous Region from January 1, 2024, were included in the study. The experimental group consisted of patients admitted to our hospital from January 1, 2020 to March 31, 2024, while the control group included 30 healthy patients admitted during the same period. A comparison of the general information and blood test results was conducted for both groups. The relationship between the variables was assessed using Spearman correlation analysis, as well as univariate and multivariate logistic regression analysis. NLR, MHR and essential hypertension .Receiver operating characteristic curves were used to predict the risk of hypertension. The experimental group exhibited significantly elevated levels of white blood cells, absolute neutrophils, red blood cells, hemoglobin, platelets, triglycerides, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, NLR, and MHR compared to the control group (P < 0.05).Elevated levels of red blood cells, hemoglobin, platelets, white blood cells, absolute neutrophils, triglycerides, total cholesterol, low-density lipoprotein cholesterol, NLR, MHR, and PLR were all found to be associated with consistent high blood pressure. Further analysis using logistic regression revealed that MHR and NLR were identified as significant independent risk factors for hypertension. The roc curve area for MHR and NLR in predicting essential hypertension risk were 0.755 and 0.652, respectively. When combined, the roc curve area increased to 0.813, with a sensitivity of 75% and a specificity of 83%. This suggests that the combination of MHR and NLR could serve as a novel inflammatory indicator for forecasting hypertension risk.

  Key words: ［Key words］ Primary hypertension; monocyte; lymphocyte; Neutrophil differential count; Platelet count; Predictive value.

  Submit time: 6 December 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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