The predictive value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in the type 2 diabeticnephropathy

Corresponding author: Liu Shiwei, 809949254@qq.com

DOI: 10.12201/bmr.202408.00066

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  Abstract: Objective To discuss the correlation of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio(PLR) with type 2 diabetic nephropathy (T2DN), and to analyze the value of NLR and PLR independently and combinedly in predicting T2DN. Methods A total of 300 patients with type 2 diabetes from the Endocrinology Department of Shanxi Bethune Hospital from December 2021 to September 2023 were analyzed retrospectively. According to the urinary albumin-creatinin ration(UACR), they were splitinto the normoalbuminuria group(A1 group, n=100), microalbuminuria group (A2 group, n=100) and the macroalbuminuria group (A3 group, n=100). The clinical and biochemical data were collected. Results NLR (2.63±1.16vs1.73±0.55，2.14±1.09vs1.73±0.55, allP<0.05) and PLR (131.32±45.79 vs101.46±26.50、115.62±41.33vs101.46±26.50, all P<0.05) were higher in A3 and A2 groups than those of A1 group. NLR and PLR were higher in A3 group than those of A2 group (2.63±1.16vs2.14±1.09、131.32±45.79vs115.62±41.33, allP<0.05).Logistic regression analysis displayed that NLR OR=1.70 (95%CI 1.29-2.25), P<0.01 and PLR OR=1.01(95%CI 1.00-1.01), P=0.03 were risk factors for T2DN. According to the analysis of ROC curves, the value of NLR for predicting T2DN was higher than PLR. The cut-off values of NLR and PLR for predicting T2DN were 1.98 and 126.14, and the AUC were 0.72 and 0.66, respectively. The corresponding sensitivity and specificity were 72.00%, 64.00% and 53.00%, 74.00%, respectively. When NLR was combined with PLR, the AUC was 0.71. The sensitivity of combined prediction was 68.00%, and the specificity was 68.50%. Conclusion NLR and PLR are both risk factors for T2DN, and both can be used to predict T2DN. NLR has the greatest predict value for T2DN. The combined predictive value of NLR and PLR were not improved compared with NLR.

  Key words: neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; Diabetic nephropathy; Type 2 diabetes

  Submit time: 27 August 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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