Research progress of histone modification and DNA methylation in diabetes nephropathy

Corresponding author: shenzhouji, shenzj2007@qq.com

DOI: 10.12201/bmr.202407.00011

•  

  Abstract: DKD is one of the most important microvascular chronic complications in diabetic patients. The main clinical manifestations are microalbuminuria, decreased glomerular filtration rate and progressive renal function impairment, which are increasingly becoming one of the main causes of death in diabetic patients. In recent years, many scholars have found that the progression of DKD is related to epigenetic mechanism, The mechanisms of epigenetics mainly include DNA methylation, histone modification and non-coding RNA. Through promoter methylation, whole genome methylation, histone ubiquitination, acetylation, phosphorylation, methylation and other molecular mechanisms aggravate renal fibrosis, inflammatory response, oxidative stress and so on. In this paper, the research progress of DNA methylation and histone modification in DKD and the treatment direction of DKD are reviewed in detail.

  Key words: Diabetic kidney disease; DNA methylation; Histone modification; Targeted therapy

  Submit time: 9 July 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
• html

• 图表

• Liu Yanan, Zhan Ming, Han Fei. Research Progress and Prospects of Finerenone in the Treatment of Diabetic Nephropathy. 2024. doi: 10.12201/bmr.202410.00033

  Bao Kaiwen. Research progress on DNA damage and immune response in autoimmune diseases. 2024. doi: 10.12201/bmr.202410.00007

  Review on therapies of basic and adjuvant of diabetic foot ulcer. 2020. doi: 10.12201/bmr.202004.00003

  zhaochengyu. Research Progress on the Relationship between Hyperuricemia and Diabetic Peripheral Neuropathy. 2024. doi: 10.12201/bmr.202408.00019

  shen pei cheng. Overview of TCM non-drug therapy of chronic kidney disease. 2024. doi: 10.12201/bmr.202409.00054

  Liu Shiwei. The predictive value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in the type 2 diabeticnephropathy. 2024. doi: 10.12201/bmr.202408.00066

  Wuhuan, Luoyushuang. Circulating Tumor Cell HER-2 Expression in the Targeted Therapy of Gastric Adenocarcinoma. 2024. doi: 10.12201/bmr.202408.00001

  LUAN Zhi-Yong. Research progress of stem cell therapy for Hirschsprung disease. 2024. doi: 10.12201/bmr.202410.00021

  liruiyao, xujingyi, daihaoyu, sunhuiwen, wutianxing. Deep confidence network-based prediction of microvascular complications in type 2 diabetes mellitus. 2024. doi: 10.12201/bmr.202404.00021

  YANG Xiaodong. Research Progress of PHLDA3 in Diseases. 2024. doi: 10.12201/bmr.202407.00029

• ID	Submit time	Number	Download
  1	2024-06-21	bmr.202407.00011V1	Download

• Public  Anonymous  To author only Submit Comments