Research Progress of PHLDA3 in Diseases

Corresponding author: YANG Xiaodong, yxdlcj@163.com

DOI: 10.12201/bmr.202407.00029

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  Abstract: PHLDA3(PleckstrinHomologyLikeDomainFamilyAMember3,PHLDA3) of the homologous domain family of Plecker substrate proteins is a protein coding gene that exists widely in human organs. It can regulate apoptosis by initiating phosphatidylinositol phosphate binding activity, responding to DNA damage of P53 mediators and participating in protein kinase B (Akt) signal transduction. In recent years, the role of PHLDA3 in various systemic diseases has attracted much attention. In this paper, the research status of PHLDA3 in diseases is reviewed.

  Key words: PHLDA3; diseases; relativity; research progress

  Submit time: 14 July 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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