Elevated HE4 levels in type 2 diabetes patients are associated with proteinuria and renal impairment

Corresponding author: zhangshipei, 24384134@qq.com

DOI: 10.12201/bmr.202409.00008

•  

  Abstract: Objective Proteinuria is a critical hallmark of early renal microvascular damage in Type 2 Diabetes Mellitus (T2DM). Previous studies have shown a close association between HE4 and renal injury, but there is limited research on the relationship between HE4 and proteinuria. This study aims to investigate the correlation of HE4 with proteinuria in patients with T2DM. Methods A total of 147 T2DM patients were enrolled in the observation group. Participants were stratified into three distinct categories according to the degree of urinary protein excretion: the macroalbuminuric group, the microalbuminuric group, and the normoalbuminuric group. 50 healthy individuals, matched for gender and age, were selected as the control group. Comparative analysis of HE4 levels across groups and their correlation with clinical parameters was conducted using univariate and multivariate linear regression to assess the association between HE4 and proteinuria. Results The correlation network diagram reveals that HE4 functions as a pivotal node linking serum albumin, urine albumin, UACR, and renal function biomarkers. Compared to the control group, HE4 levels significantly elevate in patients with type 2 diabetes mellitus (T2DM). Both univariate and multivariate linear regression analyses demonstrate a positive correlation between HE4 and UACR. Logistic regression analysis, adjusted for confounding factors including age, sex, eGFR, SCR, BUN, UA, LDH, ALB, confirms that elevated HE4 levels pose a risk factor for proteinuria (OR=1.110, 95%CI=1.005 - 1.226). Conclusion Elevated HE4 levels in patients with T2DM are significantly correlated with proteinuria, indicating a certain predictive value for proteinuria.

  Key words: Proteinuria; Human Epididymis Protein 4; Type 2 Diabetes Mellitus; Diabetic Nephropathy

  Submit time: 4 September 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
• html

• 图表

• Yu Hong, Wang Congrong, Chen Fang, Yin Shankai, Hu Cheng, Bao Yuqian, Jia Weiping, Zhang Liang, Zhu Lin. Type 2 Diabetes Health Education Knowledge Science Mapping. 2020. doi: 10.12201/bmr.202007.00001

  Liu Shiwei. The predictive value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in the type 2 diabeticnephropathy. 2024. doi: 10.12201/bmr.202408.00066

  liruiyao, xujingyi, daihaoyu, sunhuiwen, wutianxing. Deep confidence network-based prediction of microvascular complications in type 2 diabetes mellitus. 2024. doi: 10.12201/bmr.202404.00021

  shenzhouji, guofei. Research progress of histone modification and DNA methylation in diabetes nephropathy. 2024. doi: 10.12201/bmr.202407.00011

  WANG Li, PIAO Chun-li. Efficacy and safety of Yuye decoction with metformin in type 2 diabetes mellitus: A meta-analysis. 2024. doi: 10.12201/bmr.202407.00066

  wangyifan, shichaojun, maanning. Comparison of risk prediction models for atherosclerosis in type 2 diabetes mellitus. 2024. doi: 10.12201/bmr.202404.00007

  zhaochengyu. Research Progress on the Relationship between Hyperuricemia and Diabetic Peripheral Neuropathy. 2024. doi: 10.12201/bmr.202408.00019

  Liu Yanan, Zhan Ming, Han Fei. Research Progress and Prospects of Finerenone in the Treatment of Diabetic Nephropathy. 2024. doi: 10.12201/bmr.202410.00033

  Liu hongping, Yang Jie, Pang Guoming, Xing Ying, LI Penghui, Wu Ming, Wen XXiaoxiao, Li Hongjiao, Wen Tiancai. 基于改进关联规则与Logistic回归算法集成的2型糖尿病中医证型鉴别研究. 2024. doi: 10.12201/bmr.202404.00034

  chenquan, hu hongpu. Construction of Mobile Health Intervention Strategy for Elderly Diabetes Patients Based on Behavior. 2020. doi: 10.12201/bmr.202005.00245

• ID	Submit time	Number	Download
  1	2024-07-25	bmr.202409.00008V1	Download

• Public  Anonymous  To author only Submit Comments