The Application Value of Heparin Binding Protein, NLR, LMR, and PLR in Immune Function Reconstruction Evaluation in HIV/AIDS Patients

Corresponding author: Zhu Mingli, mlzhhz@163.com

DOI: 10.12201/bmr.202408.00040

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  Abstract: Objective Exploring the application value of heparin binding protein (HBP), neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), and platelet to lymphocyte ratio (PLR) in the evaluation of immune function reconstruction in human immunodeficiency virus (HIV) infected individuals/acquired immunodeficiency syndrome (AIDS) patients. Methods Collect HIV/AIDS patients from the outpatient department of Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University from January 1, 2023, to June 30, 2023. According to CD4+ T lymphocyte counts after antiretroviral treatment, categorize patients into groups with good immune function reconstruction and poor immune function reconstruction,Compare the levels of HBP, NLR, LMR, and PLR between two groups,The receiver operating characteristic curve (ROC curve) was used to evaluate the application value of HBP, NLR, LMR, and PLR in the reconstruction of patient immune function. Results The NLR and PLR of the group with good immune function reconstruction was significantly higher than that of the group with poor immune function reconstruction (P<0.05).The LMR of the group with good immune function reconstruction were significantly lower than those of the group with poor immune function reconstruction (P<0.05). The HBP between the two groups was no significant differences(P>0.05).HBP cannot evaluate whether immune function reconstruction is good in HIV/AIDS patients (P>0.05). LMR has the best efficacy in evaluating whether immune function reconstruction is good in HIV/AIDS patients (area under the curve 0.803); PLR is the second best (area under the curve 0.796); The NLR is poor (area under the curve 0.728). Conclusion HBP cannot evaluate whether immune function reconstruction is good in HIV/AIDS patients. NLR, LMR, and PLR are closely related to the immune function of HIV/AIDS patients and can be used as detection indicators to evaluate whether the immune function reconstruction of HIV/AIDS patients is good.

  Key words: Heparin binding protein； NLR；LMR；PLR；HIV/AIDS；Immune function reconstruction

  Submit time: 21 August 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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