The predictive value of FAP/ALB and NLPR in predicting the severity of CAP in the elderly

Corresponding author: yanglinying, 15633142970@163.com

DOI: 10.12201/bmr.202412.00057

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  Abstract: 【Abstract】　Objective　To explore the predictive value of the ratio of fibrin degradation products to albumin (F/A ratio), neutrophil to lymphocyte and platelet ratio (NLPR) for the severity of elderly CAP. Methods　147 elderly CAP patients hospitalized in the Department of Respiratory and Critical Care Medicine of the Affiliated Hospital of Chengde Medical College from March 2021 to March 2023 were selected and divided into non severe pneumonia group (n=94) and severe pneumonia group (n=53) according to the severity of the disease. The general and clinical data of the two groups of patients were recorded, Calculate the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), C-reactive protein to albumin ratio (CAR), F/A ratio, NLPR, and oxygenation index.Compare the differences between the two groups of the above indicators and conduct correlation analysis; Compare the predictive value of F/A ratio, NLPR, and other traditional inflammatory indicators on the severity of elderly CAP. Results　The C-reactive protein,procalcitonin,white blood cells,neutrophil,fibrin degradation products to albumin,the neutrophil to lymphocyte ratio,C-reactive protein to albumin ratio，CURB-65 scores, F/A ratio, and NLPR in the severe pneumonia group were significantly higher than those in the non severe pneumonia group, while lymphocyte,platelet and albumin were significantly lower than those in the non severe pneumonia group (P<0.05); There were no statistically significant differences in age, gender, smoking history, underlying diseases, and PLR between the two groups (P>0.05). Spearman correlation analysis showed a positive correlation between F/A ratio, NLPR, CRP, PCT, WBC, NLR, CAR, and CURB-65 scores, while a negative correlation with PaO2/FiO2 (P<0.05). Multivariate logistic regression analysis showed that F/A ratio and NLPR were independent risk factors for severe CAP in the elderly (P<0.05). The analysis of the receiver operating characteristic curve (ROC) showed that the ability of F/A ratio, NLPR, NLR, CAR, PCT, NEU, CURB-65 score, CRP, and WBC to predict the severity of elderly CAP gradually decreased(P<0.05). Conclusion　The predictive value of F/A ratio and NLPR for the severity of elderly CAP is significantly better than traditional inflammatory indicators (CRP, PCT, WBC, NEU, NLR, CAR, CURB-65 scores), which should be taken seriously by clinical workers.

  Key words: Elderly community acquired pneumonia; The ratio of fibrin degradation products to albumin; Ratio of neutro；phils to lymphocytes and platelets，predictive value

  Submit time: 24 December 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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