Changes and Significance of Coagulation Function Indicators in Elderly Patients with Severe Pneumonia

Corresponding author: Tian Jia, lceytianjia@163.com

DOI: 10.12201/bmr.202411.00035

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  Abstract: Objective To analyze the changes in coagulation function related indicators in elderly patients with severe pneumonia and explore their clinical significance. Methods 127 elderly patients with severe pneumonia admitted to the Second Peoples Hospital of Liaocheng from January 2022 to December 2023 were selected as the observation group. 135 patients with common pneumonia admitted during the same period were randomly selected as the control group. Coagulation function related indicators, including prothrombin time (PT), fibrinogen (FIB), activated partial thromboplastin time (APTT), thrombin time（TT）,D-dimer (D-D), and platelet count (PLT), were collected within 24 hours of admission from the two groups of patients. Statistical software was used to compare the positive rate and level of coagulation indicators between the two groups of patients. Results Compared with the control group, the proportion of patients in the observation group with a history of smoking and underlying diseases was significantly increased. The positive rates of PT and D-D results in the observation group were also significantly increased, and the differences were statistically significant (P<0.05). There was no significant difference in the positive rates of FIB, APTT, TT, PLT and other results between the two groups; The PT, TT, and D-D results of the observation group were significantly higher than those of the control group (P <0.05), while the PLT results were significantly lower than those of the control group (P <0.05). There was no difference in the levels of FIB and APTT results between the two groups (P >0.05). Conclusion Severe pneumonia patients often experience coagulation dysfunction, and the detection of coagulation related indicators is of great significance for evaluating the patients condition.

  Key words: Severe pneumonia; Coagulation function; Fibrinogen; D-dimer; Platelet count

  Submit time: 16 November 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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