Clinical significance of detecting blood D-dimer and CEA levels before treatment in colorectal cancer patients

Corresponding author: liu chuanlei, cz_lchl@sina.com

DOI: 10.12201/bmr.202409.00023

•  

  Abstract: Objective To investigate the relationship between the abnormal expression of pre-treatment serum CEA and D-dimer and the clinicopathological data of colorectal cancer, and to explore they effect on the recurrence, metastasis and survival rate of colorectal cancer. Methods A total of 209 patients who were diagnosed with colorectal cancer for the first time in our hospital from January 2017 to December 2018 and underwent radical surgery were enrolled, and the serum levels of D-dimer and CEA before treatment were measured, the clinicopathological data were analyzed, and the postoperative follow-up was performed. Results The positive rates of D-dimer and CEA in colorectal cancer patients were significantly higher than those in the control group (P<0.001). Pre-treatment blood D-dimer and CEA were associated with recurrence and overall survival of colorectal cancer after surgery (P<0.05). There was a correlation between pre-treatment blood D-dimer and CEA (P<0.05). Positive pre-treatmentblood D-dimer and CEA are independent factors affecting the recurrence and survival of colorectal cancer after surgery. The area under the ROC curve of the effect of both positive pre-treatmentD-dimer and CEA on overall survival was 0.723 (P<0.001). Conclusion Pre-treatment D-dimer and CEA have important value in the diagnosis and prognosis of colorectal cancer. Both positive D-dimer and CEA before treatment had a definite effect on the accuracy of postoperative survival assessment of colorectal cancer. Co-testing is of great value. And the two are related, which provides ideas for understanding the behavior of colorectal cancer.

  Key words: D-dimer; CEA; Pre-treatment; Colorectal cancer; Prognosis; ROC curve

  Submit time: 13 September 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
• html

• 图表

• HU Jie, LIU Yun-nan. Bibliometric analysis of literatures related to colorectal cancer organoids based on CiteSpace. 2024. doi: 10.12201/bmr.202409.00036

  The predictive value ofperipheral blood inflammatory makers for lower extremity deep venous thrombosis after hip fracture surgery in patients. 2024. doi: 10.12201/bmr.202408.00016

  gaoweiwei, lijialin, liudaijian, wangyulin. Correlational Analysis of Immune-Inflammatory Markers with the Clinical Outcomes of Severe Pneumonia. 2024. doi: 10.12201/bmr.202409.00062

  ZHANGCHUCHU. The application prospect of internet diagnosis and treatment in cancer patients. 2023. doi: 10.12201/bmr.202312.00026

  ZHENG Yongfei, ZHOU Minhua, YE Yiping. Study on the regularity of medication of Director Ye Yiping in the treatment of lung cancer based on data mining methods. 2024. doi: 10.12201/bmr.202407.00030

  The value of serum GP73 combined with prognostic nutritional index in the assessment of prognosis after TACE in HCC patients. 2024. doi: 10.12201/bmr.202409.00043

  wangzijin, buruiqi, buxiaojun, renjingyu, sunweiwei. Treatment of endometriosis of the abdominal wall based on the theory of Qi-blood-water. 2024. doi: 10.12201/bmr.202409.00039

  Research progress on etiology and clinical treatment of secretory otitis media. 2024. doi: 10.12201/bmr.202407.00018

  WangXin. Clinical experience of Yang Zhihong in the treatment of hypertension vertigo with hyperactivity of liver Yang. 2020. doi: 10.12201/bmr.202004.00008

  Li Yaping. Clinical Observation on the Treatment of Perimenopausal Insomnia of the Heart-kidney Disharmony Type by Regulating the Spirit and Nourishing the Heart Tang. 2024. doi: 10.12201/bmr.202408.00031

• ID	Submit time	Number	Download
  1	2024-08-11	bmr.202409.00023V1	Download

• Public  Anonymous  To author only Submit Comments