Bibliometric analysis of literatures related to colorectal cancer organoids based on CiteSpace

DOI: 10.12201/bmr.202409.00036

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  Abstract: Objective To understand the research status and hotspots of the literatures related to colorectal cancer organoid, and to explore the development trends in this field. Methods The literatures related to colorectal cancer organoid published in CNKI, Wanfang Data, VIP and Web of Science Core Collection (WoSCC) from 2014 to 2023 were searched and built into the database, and the countries, institutions, literatures and keywords were analyzed by CiteSpace software. Results There are 21 Chinese literatures in this field, which are not directly analyzed by CiteSpace software due to the small number. Finally, a total of 733 English literatures were included, and the annual publication volume showed an overall upward trend. The largest number of literatures were published by United States, followed by China, and the cooperation distribution of issuing institutions was regional. The most frequently cited literature is Patient-derived organoids model treatment response of metastatic gastrointestinal cancers. According to the keywords analysis, domestic research hotspots mainly focus on 3d culture, tumorigenesis and precision medicine, while foreign research hotspots are precision medicine, drug screening and stem cell. Self renewal, proliferation, and drug screening are the words that continue to emerge in the domestic English literatures, while the words in the foreign English literatures are tumor heterogeneity, patient derived organoid and tumor microenvironment. Conclusion There are few Chinese studies in this field, which are in the initial stage, while English studies are developing rapidly, but cross-regional and high-quality cooperation needs to be strengthened in the future. The studies in China mainly focus on basic research, and gradually turn to clinical application research. To Establish and improve the co-culture model of colorectal cancer organoid and tumor microenvironment may be the research trend in the future.

  Key words: Colorectal cancer organoids；Bibliometrics；Patient-derived organoids；CiteSpace

  Submit time: 18 September 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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