Effect of targeted temperature management on cerebrospinal fluid IL-6 in patients with severe craniocerebral injury

Corresponding author: zhanglei, 16981335@qq.com

DOI: 10.12201/bmr.202501.00079

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  Abstract: Objective To investigate the effect of targeted temperature management on Cerebrospinal fluid interleukin 6 and prognosis in patients with severe traumatic brain injury. Methods Forty patients with severe traumatic brain injury were randomly divided into two groups (normothermia group and hypothermic group, 20 cases in each group) , In normothermia group, the core temperature was controlled at 36-37.3℃，in hypothermic group, the core temperature was controlled at 35-35.9℃ for 7 days. The CSF IL-6, ICP, GCS score, Apache II score before and after treatment, the incidence of complications and GOS score after 3 months were observed. Results Compared with the normothermia group, the CSF IL-6 and ICP in the hypothermia group decreased more rapidly on the 7th day, GCS score was higher and APACHE II score was lower after treatment, GOS had a higher good prognosis rate, there were significant differences in the above indexes (P<0.05).There was no significant difference in the incidence of complications between the two groups (P>0.05). Conclusion Mild hypothermia (core temperature 35-35.9℃) can reduce the level of cerebrospinal fluid IL-6, reduce the inflammation and ICP, no increase the incidence of complications, improve the clinical prognosis in patients with severe traumatic brain injury.

  Key words: Targeted temperature management；Severe craniocerebral injury；Cerebrospinal fluid interleukin 6；Prognosis

  Submit time: 26 January 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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