The efficacy of glutamine dipeptide combined with octreotide on patients with acute pancreatitis related lung injury and its impacts on serum TLR4 and MMP-9 levels

Corresponding author: chenqiaoqiao, consider0911@163.com

DOI: 10.12201/bmr.202412.00062

•  

  Abstract: Abstract: Objective To investigate the efficacy of the combination of glutamine dipeptide and octreotide in treating severe acute pancreatitis (SAP) - related lung injury patients and their effects on serum Toll like receptor 4 (TLR4) and matrix metalloproteinase-9 (MMP-9) levels. Methods: Ninety-four patients with SAP-associated lung injury admitted to our hospital from June 2022 to June 2024 were selected and randomly divided into an observation group and a control group, with octreotide treatment in the control group and prolylglutamine treatment in the observation group (on the basis of the control group). The efficacy, the changes in severity of the condition (Balthazar CT score, APACHE II score, MLIS score), serum TLR4, MMP-9, and blood gas indicators arterial partial pressure of oxygen (PaO2), blood oxygen saturation (SaO2), and oxygenation index before and after treatment were compared between the two groups. Results The observation group showed better efficacy (P<0.05). Compared with before treatment, the Balthazar CT score, APACHE II score, MLIS score, serum TLR4, MMP-9 levels in both groups obviously decreased after treatment, while PaO2, SaO2, and oxygenation index obviously increased, and the observation group was better (P<0.05). Conclusion: The combination of glutamine dipeptide and octreotide is effective in treating patients with SAP related lung injury, it can improve the clinical symptoms of patients, reduce lung injury, inhibit inflammatory reactions, improve blood gas indicators, and promote patient recovery

  Key words: Glutamine dipeptide; Octreotide; Severe acute pancreatitis; Related lung injury; Efficacy; Toll like receptor 4; Matrix metalloproteinase-9

  Submit time: 25 December 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
• html

• 图表

• Xu Xiuying, Wu Wenting. The research progress on the association between MMP-9 and schizophrenia and its therapeutic prospects.. 2024. doi: 10.12201/bmr.202407.00065

  The role of minimal RNA in sepsis-related acute kidney injury. 2024. doi: 10.12201/bmr.202410.00011

  zhangshipei, chujinshen, xueguohui, wanfang, caojunda, chenkeqi, chenjing, liuxiaofeng, chenxueli. Elevated HE4 levels in type 2 diabetes patients are associated with proteinuria and renal impairment. 2024. doi: 10.12201/bmr.202409.00008

  Wu, 程, Liu. Advances in Surgical Treatment for Infected Necrotizing Pancreatitis. 2024. doi: 10.12201/bmr.202409.00060

  Establishment and validation of a risk early warning model for recurrent readmission in patients with hypertriglyceridemic acute pancreatitis in the short term. 2024. doi: 10.12201/bmr.202408.00010

  Wangzhong. Correlation of Serum soluble TREM2 with Acute coronary syndrome in the elderly. 2024. doi: 10.12201/bmr.202412.00086

  liushunlin. The expression of CPNE1 and ZWILCH in the progression of lung adenocarcinoma and their correlation with prognosis. 2024. doi: 10.12201/bmr.202406.00030

  颜林朗, Fan Heng. The application value of proenkephalin 119-159 in septic acute kidney injury. 2024. doi: 10.12201/bmr.202408.00070

  TANG Kan-kai, LIU Feng-qi, CHEN Zhi-dong. Effects of α7 nicotinic acetylcholine receptor agonist on intestinal injury and mitochondrial autophagy in sepsis mice. 2024. doi: 10.12201/bmr.202410.00066

  LIU Rui, LIU Xiao-li, JIN Ze-hong. Analysis of application value and related factors for left ventricular? global longitudinal strain in early cardiac function injury in patients with diabetes mellitus. 2024. doi: 10.12201/bmr.202411.00042

• ID	Submit time	Number	Download
  1	2024-11-08	bmr.202412.00062V1	Download

• Public  Anonymous  To author only Submit Comments