Research progress related to biomarkers of acute Kidney injury

Corresponding author: lishujyu, lsj20051029@126.com

DOI: 10.12201/bmr.202508.00028

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  Abstract: The complex pathological mechanisms and multifactorial etiology of acute kidney injury (AKI) pose significant challenges to traditional diagnostic approaches. Current diagnostic criteria relying on serum creatinine (Scr) and urine output exhibit inherent limitations, including insufficient specificity and delayed sensitivity, particularly in complex clinical scenarios. This article reviews the biological characteristics and clinical utility of emerging biomarkers—such as soluble urokinase plasminogen activator receptor (suPAR) and proenkephalin (PENK)—to address the shortcomings of conventional biomarkers in AKI diagnosis.

  Key words: acute renal injury; biomarker; diagnose; prediction model; artificial intelligence

  Submit time: 12 August 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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