Advances in Research on the Aggressive Nature of PitNETs Using Serological Markers in Combination with Imaging Biomarkers

DOI: 10.12201/bmr.202508.00037

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  Abstract: Pituitary neuroendocrine tumors (PitNETs) exhibit significant heterogeneity, and their aggressive characteristics and complex clinical manifestations pose challenges for early diagnosis and treatment. The aggressive diagnosis usually relies on the confirmation of postoperative pathological tissue, while serum markers and imaging can be obtained preoperatively and can be non-invasively monitored dynamically. At the same time, the imaging features can effectively reflect the biological behavior of the tumor. In recent years, with the development of biomedical technology, the combination of serological markers such as IGF-1, GH, PRL, ACTH, and TSH with imaging cytology has opened up new research areas for the invasion prediction of PitNETs. This combined method not only improves the accuracy of invasion prediction, but also provides new ideas for individualized treatment. However, there are still some technical challenges in practical application, including the standardization of marker selection, the complexity of image data processing, and the feasibility of clinical transformation. This article will comprehensively review the latest research progress of serological markers and imaging genomics in the invasion prediction of PitNETs, analyze the potential advantages of their joint application, explore the technical challenges faced, and discuss the future development trends. By systematically integrating the existing research results, it aims to provide valuable reference for clinical application and subsequent related research.

  Key words: pituitary neuroendocrine tumor; Ki-67 index; imaging; serological markers; invasive prediction

  Submit time: 18 August 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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• ID	Submit time	Number	Download
  2	2025-06-15	bmr.202508.00037V2	Download
  1	2025-06-16	bmr.202508.00037V1	Download

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