Predictive Value of First-Trimester Serological Markers PAPP-A and Free-hCGβ Combined with Gestational Weight Gain for Fetal Growth Restriction
????????????? Yang Wenying1? Yang Xiaoyan▲

Corresponding author: yangxiaoyan, 1198492182@qq.com

DOI: 10.12201/bmr.202505.00018

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  Abstract: Objective To analyze the relationship between first-trimester serological screening markers pregnancy-associated plasma protein-A(PAPP-A), free beta-human chorionic gonadotropin (free-hCGβ), gestational weight gain (GWG), and fetal growth restriction (FGR), and to explore their predictive value for FGR. Method A retrospective study was conducted on 426 FGR patients (case group) who underwent regular prenatal care, first-trimester serological screening, and delivered at Inner Mongolia Maternal and Child Health Care Hospital from January 1, 2021, to January 2024. A control group of 520 normal-weight singleton pregnancies from the same period was randomly selected. SPSS 24.0 was used to analyze maternal characteristics and serological data. Receiver operating characteristic (ROC) curves were generated to evaluate the predictive value of serological markers and GWG for FGR. Results(1)Maternal age in the FGR group (31.49 ± 2.29 years) was higher than in the control group (30.89 ± 2.20 years,P< 0.05). GWG, PAPP-A, and free-hCGβ levels were significantly lower in the FGR group (P< 0.05).(2)Advanced maternal age, decreased PAPP-A, reduced free-hCGβ, and insufficient GWG were identified as independent risk factors for FGR.(3)The combined predictive model (PAPP-A, free-hCGβ, maternal age, and GWG) achieved an AUC of 0.806 (95% CI: 0.778–0.834) for FGR prediction. ConclusionKey factors influencing FGR include PAPP-A, free-hCGβ, maternal age, and GWG. The combination of these markers demonstrates high predictive value for FGR.

  Key words: Fetal growth restriction; Pregnancy-associated plasma protein-A; Gestational weight gain; Free beta-human chorionic gonadotropin

  Submit time: 19 May 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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