Research Progress on Autophagy-Dependent Ferroptosis in Cancer

Corresponding author: yangyang, 35112908@qq.com

DOI: 10.12201/bmr.202410.00029

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  Abstract: Autophagy is a vital process involved in cellular and tissue regeneration, exhibiting various mechanisms of action in different tumor cells. Ferroptosis is a form of non-apoptotic cell death characterized by iron accumulation and excessive lipid peroxidation. Excessive autophagy can trigger ferroptosis in cancer cells, a phenomenon referred to as autophagy-dependent ferroptosis. As an emerging mechanism of cell death, this article primarily elucidates the anti-tumor mechanisms of autophagy-dependent ferroptosis through recent advancements involving natural compounds, nanomaterials, and gene interference, aiming to provide new strategies and insights for cancer therapy.

  Key words: Autophagy, Ferroptosis, Autophagy-dependent; Ferroptosis, Cancer

  Submit time: 11 October 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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