通讯作者: 章涛, 50114463@163.com

DOI：10.12201/bmr.202501.00031

Analysis of the difference between VCIND and cognitively normal cerebrovascular disease

• 摘要：目的:分析非痴呆型血管性认知功能障碍(VCIND)与认知正常脑血管病患者的脑血管形态学及血清学相关指标差异。方法:选取2023年6月-2024年9月入住我院神经内科的VCIND患者100例为研究组,同时期的100例认知正常脑血管病患者为对照组,采用全脑血管造影及血清学检查,分析两组脑动脉延长扩张、血管狭窄、侧支循环建立及炎症因子,血脂代谢指标的差异性,并探究研究组不同责任血管病变患者与认知障碍严重程度的关系。结果:研究组脑动脉延长扩张总占比高于对照组(P＜0.05)；研究组无狭窄率低于对照组(P＜0.05)；研究组侧支循环建立率低于对照组(P＜0.05)；研究组入院前、接受治疗前的炎症因子水平均低于对照组(P＜0.05)；研究组入院前、接受治疗前的总胆固醇(TC)、低密度脂蛋白(LDL)、载脂蛋白B(ApoB)及脂蛋白aLp(a)水平高于对照组,高密度脂蛋白(HDL)水平低于对照组(P＜0.05)；大脑前动脉血管病变在各脑动脉血管病变中认知功能评分最低,组间比较差异无统计学意义(P＞0.05)。结论:通过对比分析,证实脑动脉延长扩张、狭窄严重、无侧支循环建立,炎症反应明显及代谢异常等特征患者是发生VCIND的高危人群,针对该类患者需早期进行认知干预,预防VCIND发生。

  关键词： VCIND; 认知正常脑血管病; 脑血管形态学; 血清学相关指标

   

  Abstract: Objective To analyze the differences of cerebral vascular morphology and serologic indexes between non-demented vascular cognitive impairment (VCIND) and cognitively normal cerebral vascular disease. Methods A total of 100 VCIND patients admitted to the Department of Neurology of our hospital from June 2023 to September 2024 were selected as the study group, and 100 cognitively normal cerebrovascular disease patients of the same period were selected as the control group. By means of cerebrovascular angiography and serological examination, the differences of cerebral artery dilation, vascular stenosis, collateral circulation establishment, inflammatory factors and lipid metabolism indexes between the two groups were analyzed. And to explore the relationship between the severity of cognitive impairment and the patients with different responsibility vascular diseases. Results The total proportion of cerebral artery elongation and dilation in the study group was higher than that in the control group (P<0.05). The stenosis free rate of the study group was lower than that of the control group (P<0.05). The establishment rate of collateral circulation in the study group was lower than that in the control group (P<0.05). The levels of inflammatory factors in the study group were lower than those in the control group before admission and treatment (P<0.05). The levels of total cholesterol (TC), low-density lipoprotein (LDL), apolipoprotein B (ApoB) and lipoprotein aLp (a) in the study group were higher than those in the control group before admission and treatment, and the levels of high density lipoprotein (HDL) were lower than those in the control group (P<0.05). Cerebral anterior artery vascular disease had the lowest cognitive function score among all cerebral artery vascular diseases, and there was no statistical significance between groups (P>0.05). Conclusion Through comparative analysis, it was confirmed that patients with cerebral artery elongation and dilation, severe stenosis, no establishment of collateral circulation, obvious inflammatory response and metabolic abnormalities were high-risk groups for the occurrence of VCIND, and early cognitive intervention was needed for these patients to prevent the occurrence of VCIND.

  Key words: VCIND; Cognitive normal cerebrovascular disease; Cerebrovascular morphology; Serological related indicators

  提交时间：2025-01-10

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• 序号	提交日期	编号	操作
  1	2024-11-24	bmr.202501.00031V1	下载

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