通讯作者: 毕方平, 929738900@qq.com

DOI：10.12201/bmr.202411.00042

Analysis of application value and related factors for left ventricular? global longitudinal strain in early cardiac function injury in patients with diabetes mellitus

• 摘要：目的:通过二维斑点追踪成像技术,分析左室整体长轴应变在糖尿病早期心功能损伤中的应用价值及相关因素分析。 方法:选取45例2023年1月至2024年1月来我院内分泌科就诊的糖尿病为研究对象。所有研究临床资料及超声心动图资料完整。根据糖化血红蛋白(HbA1c)高低分为A(≤11.5%)、B(＞11.5%)两组,比较两组患者临床资料及超声心动图资料的差异。通过单因素及多因素线性回归,分析各临床资料及超声心动图资料与左室整体长轴的关系。通过绘制ROC曲线,评估糖化血红蛋白对LVGLS的诊断效能。? 结果:45例LVEF值正常的研究对象当中,24例患者LVGLS下降(53.3%)。与A组患者相比,B组患者体重、LVGLS减低,HbA1c、IVST明显增高,差异有统计学意义(均P＜0.05),其他临床资料及超声心动图资料差异均无统计学意义。通过线性回归分析,发现HbA1c与LVGLS存在线性关系(β值为-0.511)。通过ROC曲线分析,发现当HbA1c为12.65%时,其诊断LVGLS的ROC曲线下面积(AUC)最大,值为0.746,敏感性100%,特异性75%。 结论:对于糖尿病患者,体重、IVST、LVGLS可能与HbA1c有关；糖尿病患者HbA1c增高是LVGLS 的独立危险因素；HbA1c判断LVGLS是否下降具有较高的诊断价值。

  关键词： 糖尿病；糖化血红蛋白；二维斑点追踪技术；左室整体长轴应变；超声心动图；; ; ; ; 

   

  Abstract: Objective:To analyse the application value and related factors for left ventricular? global longitudinal strain in early cardiac function injury in patients with diabetes mellitus by two-dimensional speckle tracking echocardiography. Methods:Forty-five patients with diabetes who came to our endocrinology department from January 2023 to January 2024 were selected as the study objects.The clinical and echocardiographic data of all patients were complete.According to the level of HbA1c, patients were divided into group A (≤11.5%) and groups B (> 11.5%) .The clinical data and echocardiographic data from the two groups were compared.The relationship between clinical, echocardiographic data and left ventricular global longitudinal strain was analyzed by univariate and multivariate linear regression.ROC curve was plotted to evaluate the diagnostic efficacy of HBA1c in LVGLS.Results :Of the 45 subjects with normal LVEF levels, LVGLS decreased in 24 (53.3%).Compared with group A, body weight, LVGLS were? reduced and HbA1c,IVST were significantly increased in group B , and the differences were statistically significant (all P < 0.05).There were no significant differences in other clinical and echocardiographic data.By linear regression analysis, it was found that HbA1c had a linear relationship with LVGLS (β value was -0.511).Through ROC curve analysis, it was found the area? under the curve (AUC) for diagnosing LVGLS was largest when the cutoff value of HbA1c was 12.65%, with an area of 0.746, sensitivity of 100% and specificity of 75%.Conclusions:For diabetic patients, body weight, IVST,LVGLS may be related to HbA1c; Increased HbA1c in diabetic patients is an independent risk factor for LVGLS. HbA1c is of high diagnostic value in determining whether LVGLS decreases.

  Key words: diabetes mellitus; Glycosylated hemoglobin; two-dimensional speckle tracking technology; Left ventricular global longitudinal strain; echocardiography

  提交时间：2024-11-20

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• 序号	提交日期	编号	操作
  1	2024-10-21	bmr.202411.00042V1	下载

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