通讯作者: 吴照科, w20220901123@163.com

DOI：10.12201/bmr.202501.00044

Exploring the Risk Factors for Cardiovascular Disease in Rheumatoid Arthritis Patients Based on Inflammatory Markers

• 摘要：摘 要 目的：联合多种炎症指标，分析类风湿性关节炎（rheumatoid arthritis，RA）并发心血管疾病（cardiovascular disease，CVD）的危险因素。方法：收集2023年1月至2024年9月在郑州大学第二附属医院住院的225例RA患者资料，采用回顾性分析方法，通过单因素和多因素回归分析RA患者并发CVD的危险因素。结果：在225例RA患者中，50例合并心血管疾病（22.2%）。单因素分析结果显示，年龄、红细胞比容、红细胞体积分布宽度（red blood cell distribution width，RDW）、血沉、中性粒细胞计数/高密度脂蛋白比值（NHR）、血小板计数/淋巴细胞计数比值（PLR）与RA患者并发CVD相关 (P<0.05)；多因素分析结果显示，年龄（OR=1.131，95%CI=1.076,1.209）、RDW（OR=0.123，95%CI=1.006,1.272）、NHR（OR=0.471，95%CI=1.116,2.279）、PLR（OR=0.018，95%CI=1.008,1.028）均为RA患者并发CVD的危险因素(P<0.05)。受试者工作特征（receiver operating characteristic，ROC）曲线分析结果显示，年龄、RDW、NHR、PLR的曲线下面积（area under curve，AUC）分别为0.844、0.797、0.572、0.713。多指标联合诊断时，其AUC为0.898。结论：联合年龄、RDW、NHR及PLR可用于RA并发CVD的早期诊断并改善RA患者的生存质量。

  关键词： 类风湿性关节炎；心血管疾病；中性粒细胞计数；血小板计数；高密度脂蛋白; ; ; ; 

   

  Abstract: ABSTRACT Objective: To analyze the risk factors for cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA) by integrating multiple inflammatory markers. Methods: Clinical data of 225 RA patients hospitalized at the Second Affiliated Hospital of Zhengzhou University from January 2023 to September 2024 were collected for a retrospective analysis. Univariate and multivariate regression analyses were conducted to identify risk factors for CVD in RA patients. Results: Among the 225 RA patients, 50 (22.2%) were diagnosed with CVD. Univariate analysis showed that age, hematocrit, red blood cell distribution width (RDW), erythrocyte sedimentation rate (ESR), neutrophil count/high-density lipoprotein cholesterol ratio (NHR), and platelet count/lymphocyte count ratio (PLR) were associated with the occurrence of CVD in RA patients (P<0.05). Multivariate analysis revealed that age (OR=1.131, 95%CI=1.076–1.209), RDW (OR=1.123, 95%CI=1.006–1.272), NHR (OR=1.471, 95%CI=1.116–2.279), and PLR (OR=1.018, 95%CI=1.008–1.028) were independent risk factors for CVD in RA patients (P<0.05). Receiver operating characteristic (ROC) curve analysis indicated that the areas under the curve (AUC) for age, RDW, NHR, and PLR were 0.844, 0.797, 0.572, and 0.713, respectively. The AUC of the combined diagnostic model reached 0.898, outperforming individual markers. Conclusion: The combination of age, RDW, NHR, and PLR can be used for the early diagnosis of CVD in RA patients, improving diagnostic accuracy and patient outcomes.

  Key words: rheumatoid arthritis; cardiovascular disease; neutrophil count; platelet count; high-density lipoprotein

  提交时间：2025-01-15

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
• html

• 图表

• 岳晓波, 赵兴胜. 血清MHR、NLR及PLR与原发性高血压的相关性研究. 2024. doi: 10.12201/bmr.202411.00052

  何景梅, 张晓玲, 陈琨. 系统性炎症反应指数、乳酸脱氢酶及谷草转氨酶用于识别成人暴发性心肌炎高危人群的价值分析. 2024. doi: 10.12201/bmr.202410.00070

  牛亚丹. 外周血炎症指标对髋部骨折患者术后并发下肢深静脉血栓的诊断价值. 2024. doi: 10.12201/bmr.202408.00016

  冀鹏磊, 髙崴崴, 李佳霖, 刘待见, 王昱林. 免疫炎症相关指数与重症肺炎转归相关性分析. 2024. doi: 10.12201/bmr.202409.00062

  史洋溢, 吴勇. 血小板膜糖蛋白抗体的差异性分布对儿童原发免疫性血小板减少症临床疗效影响的研究并文献复习. 2024. doi: 10.12201/bmr.202407.00049

  邵旭华, 陈志明, 魏杰, 许一帆, 李少华. t-P1NP/β-CTX与膝骨关节炎患者补肾壮骨汤疗效的相关性. 2025. doi: 10.12201/bmr.202501.00050

  章涛. VCIND与认知正常脑血管病患者脑血管形态学及血清学相关指标差异分析. 2025. doi: 10.12201/bmr.202501.00031

  王玥琳, 蒋运兰, 李乐, 陈红, 王镜, 张梦洁, 白小雨, 武森林. 多发性骨髓瘤化疗后患者住院感染危险因素的Meta分析. 2025. doi: 10.12201/bmr.202501.00012

  李思颉, 刘芳艳, 贺明轶, 梁潇, 王长远, 常莹▲. 基于超声技术的急诊心脑疾病教学方法的探索. 2024. doi: 10.12201/bmr.202407.00022

  梁登耀, 刘师伟. NLR、PLR对2型糖尿病肾病的预测价值. 2024. doi: 10.12201/bmr.202408.00066

• 序号	提交日期	编号	操作
  1	2025-01-09	bmr.202501.00044V1	下载

• 公开评论  匿名评论  仅发给作者 提交评论