通讯作者: 徐霞红, lmm02075@glhospital.com

DOI：10.12201/bmr.202503.00012

Exploring the relationship between serum ferritin and metabolic-associated fatty liver disease in adolescents based on NHANES database

• 摘要：目的 探讨血清铁蛋白与青少年代谢相关脂肪性肝病(metabolic-associated fatty liver disease,MAFLD)的相关性。 方法 本研究基于2017~2020年NHANES数据库,最终纳入559名12~18岁青少年,分为MAFLD组(119例)和非MAFLD组(440例)。收集研究对象基本信息、血清铁代谢指标、肝功能、血脂、血糖等数据,并通过瞬时弹性成像(VCTE)评估肝脂肪变性和纤维化。采用Pearson相关性分析及logistic回归分析评估血清铁蛋白与MAFLD的关系。结果 MAFLD组血清铁蛋白水平显著高于非MAFLD组(P＜0.05)。Pearson相关性分析结果显示,血清铁蛋白与受控衰减参数(Controlled Attenuation Parameter,CAP)、肝硬度值(Liver Stiffness Measurement,LSM)、身体质量指数(Body Mass Index, BMI)、丙氨酸氨基转移酶、γ-谷氨酰基转移酶、甘油三酯、尿酸水平呈正相关(P＜0.05),与高密度脂蛋白胆固醇水平呈负相关(P＜0.05)。Logistic回归分析结果显示,未调整变量时,血清铁蛋白最高四分位组(Q4)MAFLD风险显著增加；调整性别、年龄、种族、BMI等因素后,该相关性不显著,但BMI(OR=1.250,95%CI=1.176~1.329)、球蛋白(OR=2.991,95%CI=1.218~7.343)、丙氨酸氨基转移酶(OR=1.052,95%CI=1.003~1.104)、白细胞计数(OR=1.225,95%CI=1.041~1.441)水平是MAFLD的独立危险因素。结论 血清铁蛋白水平在青少年MAFLD中显著升高,但与MAFLD的发生无独立相关性。BMI、球蛋白、ALT及白细胞计数是青少年MAFLD的重要危险因素。

  关键词： 代谢相关脂肪性肝病; 血清铁蛋白; 青少年

   

  Abstract: Objective To investigate the relationship between serum ferritin and metabolic-associated fatty liver disease (MAFLD) in adolescents. Methods This study utilized data from the 2017~2020 NHANES database, ultimately including 559 adolescents aged 12~18 years, divided into the MAFLD group (119 cases) and the non-MAFLD group (440 cases). Data on demographic characteristics, serum iron metabolism indicators, liver function, lipid profiles, glucose levels, and other relevant parameters were collected. Liver steatosis and fibrosis were assessed using vibration-controlled transient elastography (VCTE). Pearson correlation and logistic regression analyses were performed to evaluate the relationship between serum ferritin and MAFLD. Results Serum ferritin levels were significantly higher in the MAFLD group compared to the non-MAFLD group (P<0.05). Pearson correlation analysis indicated that serum ferritin was positively correlated with the controlled attenuation parameter (CAP), liver stiffness measurement (LSM), body mass index (BMI), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), triglycerides, and uric acid levels (P<0.05), but negatively correlated with high-density lipoprotein cholesterol levels (P<0.05). Logistic regression analysis revealed that while the risk of MAFLD significantly increased in the highest quartile of serum ferritin (Q4) without adjusting for covariates, this association disappeared after adjusting for gender, age, race, BMI, and other factors. BMI (OR=1.250, 95%CI=1.176~1.329), globulin (OR=2.991, 95%CI=1.218~7.343), ALT (OR=1.052, 95%CI=1.003~1.104), and white blood cell count (OR=1.225, 95% CI=1.041~1.441) were identified as independent risk factors for MAFLD. Conclusion Serum ferritin levels are significantly elevated in adolescents with MAFLD but are not independently associated with the occurrence of MAFLD. BMI, globulin, ALT, and white blood cell count are important risk factors for adolescent MAFLD.

  Key words: Metabolic-associated fatty liver disease; serum ferritin; Adolescents

  提交时间：2025-03-05

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• 序号	提交日期	编号	操作
  1	2025-02-24	bmr.202503.00012V1	下载

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