通讯作者: 吕文平, lvwenping301@126.com

DOI：10.12201/bmr.202204.00003

Correlation between psychological stress and metabolic-associated fatty liver disease

• 摘要：目的 探究心理压力与代谢相关脂肪性肝病（Metabolic-associated fatty liver disease，MAFLD）的相关性，为MAFLD的治疗需结合心理干预的新理念提供依据。方法 分析2017年1月～2020年12月于解放军总医院健康医学科行体格检查者的病史和体检资料，利用PSS-14压力感知量表评估参与者过往1月内的心理压力水平，利用χ2检验和单因素分析筛选MAFLD患病相关变量，经调整混杂因素后，将有统计学意义的变量纳入logistic多因素回归分析。结果 纳入参与者19999例，其中MAFLD患病率46.4%（9281/19999），高水平心理压力的人群占比34.5%（6908/19999），平均年龄46.3岁，其中男性78.2%（5407/6908），女性21.8%（1501/6908）。多因素logistic回归分析显示，心理压力是MAFLD患病的危险因素（OR=1.173，95% CI：1.093～1.259）。结论 心理压力是MAFLD的危险因素，对于MAFLD高风险人群临床上有必要积极评估心理精神健康状态，做到早期预防和干预。

  关键词： 代谢相关脂肪性肝病; 心理压力; 风险因素

   

  Abstract: Objective To investigate the correlation between psychological stress and metabolically associated fatty liver disease (MAFLD), and to provide a basis for the new concept of psychological intervention in the treatment of MAFLD. Methods The medical history and physical examination data of people who underwent physical health examinations in the Department of Health Management Institute, PLA General Hospital from January 2017 to December 2020, were analyzed, and the PSS-14 Stress Perception Scale was used to assess psychological stress level of the participants in the past 1 month. The variables related to the prevalence of MAFLD were screened by χ2 test and univariate analysis. After adjusting for confounding factors, the variables with statistical significance in univariate analysis were included in logistic multivariate regression analysis. Results A total of 19,999 participants were included, of which the prevalence of MAFLD was 46.4% (9281/19999), the population with high-level psychological stress accounted for 34.5% (6908/19999), with an average age of 46.3, males among them accounted for 78.2% (5407/6908) and 21.8% (1501/6908) of females. Multivariate logistic regression analysis showed that psychological stress is a risk factor for MAFLD (OR=1.173,95% CI:1.093~1.259). Conclusion Psychological stress is a risk factor for MAFLD, and it is necessary to actively evaluate the psychological and mental health status of people with high hazards of MAFLD in clinical practice, to achieve early prevention and intervention.

  Key words: Metabolic-associated fatty liver disease; Psychological stress; Risk factors

  提交时间：2022-04-14

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• 序号	提交日期	编号	操作
  1	2022-04-14	bmr.202204.00003V1	下载

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