通讯作者: 邱伟文, weiwenq@hotmail.com

DOI：10.12201/bmr.202411.00015

Correlating White Matter Hyperintensities Severity with Collateral Disease Syndrome Type Distribution

• 摘要：【摘要】目的 探讨脑白质高信号（WMH）严重程度与络病学证型的分布关系情况。方法 采用横断面调查,纳入208例符合标准的脑小血管病WMH患者。所有入组研究对象均完成络病学辨证分型，在磁共振液体衰减反转恢复（FLAIR）序列图像上对WMH进行Fazekas评分及体积的测量。结果 在208例患者当中，脑络失荣型52例（25.00%），Fazekas评分为3（2，3），WMH体积分别为（8.80±9.37）ml；脑络瘀阻型67例（32.21%），Fazekas评分为4（3，4），WMH体积分别为（13.42±9.18）ml；脑络绌急型47例（22.60%），Fazekas评分为4（3，5），WMH体积分别为（14.60±10.07）ml；脑络瘀塞型42例（20.19%），Fazekas评分为4（4，5），WMH体积分别为（18.65±10.71）ml。其中Fazekas评分为1-2分的患者55例（26.44%）以脑络失荣最为常见，3-4分有105例（50.48%）以脑络瘀阻型最为常见，5-6分有48例为（23.08%）以脑络瘀塞型最为常见。脑络失荣型、脑络瘀塞型与其他证型之间在Fazekas评分、WMH体积方面的差异具有统计学意义（P<0.05)；脑络瘀阻型与脑络绌急型之间则无统计学意义（P>0.05)。结论 WMH严重程度与络病证型分布具有一定的对应关系，且可作为评估络病患者病情严重程度的参考指标。

  关键词： 络病学；辨证分型；脑白质高信号；脑小血管病; ; ; 

   

  Abstract: 【Abstract】 Objective To explore the relationship between the severity of white matter hyperintensities (WMH) and the distribution of collateral disease syndrome types. Methods A cross-sectional study was conducted, including 208 patients with cerebral small vessel disease and white matter hyperintensities who met the criteria. All enrolled subjects in the study completed the collateral disease syndrome differentiation. WMH was graded on magnetic resonance imaging fluid-attenuated inversion recovery (FLAIR) sequences using the Fazekas scale and measured for volume. Results Among the 208 patients, there were 52 cases (25.00%) of the Brain Collateral Impoverishment (BCI) type, with a Fazekas score of 3 (2, 3), and WMH volume of (8.80±9.37) ml; 67 cases (32.21%) of the Brain Collateral Stasis (BCS) type, with a Fazekas score of 4 (3, 4), and WMH volume of (13.42±9.18) ml; 47 cases (22.60%) of the Brain Collateral Constraint (BCC) type, with a Fazekas score of 4 (3, 5), and WMH volume of (14.60±10.07) ml; and 42 cases (20.19%) of the Brain Collateral Occlusion (BCO) type, with a Fazekas score of 4 (4, 5), and WMH volume of (18.65±10.71) ml. Of these, 55 patients (26.44%) with a Fazekas score of 1-2 were most commonly of the BCI type, 105 patients (50.48%) with a score of 3-4 were most commonly of the BCS type, and 48 patients (23.08%) with a score of 5-6 were most commonly of the BCO type. There were statistically significant differences in Fazekas scores and WMH volumes between the BCI and BCO types and other syndrome types (P<0.05), but no significant differences were observed between the BCS and BCC types (P>0.05).Conclusion The severity of WMH corresponds to a certain distribution of collateral disease syndrome types, and can serve as a reference indicator for assessing the severity of illness in patients with collateral disease.

  Key words: collateral disease; syndrome differentiation; white matter hyperintensities; cerebral small vessel disease.

  提交时间：2024-11-08

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• 序号	提交日期	编号	操作
  1	2024-10-07	bmr.202411.00015V1	下载

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