Risk factors and prognostic analysis of early myocardial injury after acute carbon monoxide poisoning

Corresponding author: Jin Ling, 1171449903@qq.com

DOI: 10.12201/bmr.202504.00060

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  Abstract: Objective:To explore the risk factors of early myocardial injury in patients with acute carbon monoxide poisoning (ACOP) and the effect of myocardial injury on prognosis. Methods:176 patients with ACOP treated in the Department of Neurology of the First Peoples Hospital of Changde City from January 2020 to November 2024 were selected, of which 80 were male and 96 were female. According to the highest value of CK-MB within 72h after poisoning, the patients were divided into the early myocardial injury group (CK-MB≥75 U/L, n=32 cases) and the non-early myocardial injury group (CK-MB<75 U/L, n=144 cases). The clinical data of the two groups were collected and compared, and a binary logistic multifactor regression model was applied to explore the independent influencing factors of ACOP patients with concurrent early myocardial injury, and the predictive efficacy of the risk factors for early myocardial injury was further analysed by plotting the subjects work characteristics (ROC) curves. Results:The differences in gender, age, underlying diseases (hypertension, diabetes mellitus, coronary heart disease, stroke), and personal history (smoking, alcohol consumption) between the two groups were not statistically significant (P>0.05). The levels of NLR, MLR, ALT, AST, BUN, and CRP were higher in the early myocardial injury group than in the non-early myocardial injury group, and the differences were statistically significant (P < 0.05). Further multifactorial logistic regression analysis showed that AST and CRP were independent risk factors for early myocardial injury in ACOP patients (P<0. 05). The combined diagnostic ROC curve showed that the sensitivity of AST combined with CRP in predicting early myocardial injury in patients with ACOP was 78.1%, the specificity was 93.1%, and the AUC was 0.931. The incidence of DEACMP in patients with early myocardial injury group was significantly higher than that in patients with non-early myocardial injury group (χ 2=19.055, P<0.01). Conclusion:AST and CRP are independent risk factors for early myocardial injury in ACOP patients, and AST combined with CRP has a certain predictive value for early myocardial injury in ACOP patients. The incidence of DEACMP was higher in the early myocardial injury group, suggesting that myocardial injury is closely related to the poor prognosis of patients.

  Key words: acute carbon monoxide poisoning; early myocardial injury; aspartate aminotransferase; C-reactive protein

  Submit time: 18 April 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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