Relationship of Human Neutrophil Peptides with the severity and prognosis of Acute Respiratory Distress Syndrome

DOI: 10.12201/bmr.202410.00060

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  Abstract: Objective To investigate the relationship of human neutrophil peptides(HNPs) with the severity and prognosis in acute respiratory distress syndrome(ARDS) patients. Methods From December 2021 to December 2023, 80 ARDS patients were enrolled in the study. Plasma samples were taken within 24h after admission to ICU, HNPs concentration was then measured with enzyme-linked immune sorbent assay(ELISA). Differences in HNPs concentration and APACHE II score were compared in survival group (n=48) and non-survival group (n=32) based on their 28-days outcomes. The correlation between HNPs concentration and APACHE II score were calculatedbySpearman correlation analysis. Prognostic factors of 28-day-mortaliy were analyzed and the early predictors of most sensitive prognostic factor were explored by Multivariate logistic regression analysis. Results For ARDS patients 28-days outcome, HNPs concentration and APACHE II score of non-survival group was significantly increased than survival group(p<0.05). HNPs concentration has a positive correlation with APACHE II score(r=0.344, p<0.05). HNPs was an independent prognosis factor of 28-day mortality of ARDS patients. Conclusion Plasma HNPs concentration may be early used to evaluate the severity and prognosis of ARDS patients.

  Key words: ARDS; Human neutrophil peptides(HNPs); APACHE II score; Prognosis

  Submit time: 21 October 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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