Prognostic Value of pSOFA Score Combined with AGI Grade in Children with Sepsis

Corresponding author: wangyumin, wangyumin080102@163.com

DOI: 10.12201/bmr.202411.00002

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  Abstract: Objective: To investigate the prognostic factors of acute gastrointestinal injury (AGI) in children with sepsis, and to explore the predictive value of Pediatric Sequential Organ Failure Assessment (pSOFA), AGI grade and their combined scores for prognosis.Methods:A total of 143 children with sepsis complicated with AGI from January 2020 to January 2022 were selected and divided into severe sepsis group and septic shock group according to the severity of disease. The clinical data and their outcomes were collected, and the pSOFA score was obtained on the day when sepsis was diagnosed. AGI was evaluated every day during hospitalization, and the highest value was selected and added to the pSOFA score to get the joint score. Multivariate Logistic regression was used to identify the independent factors affecting the outcome. The receiver operating characteristic (ROC) curve was used to analyze the predictive value of pSOFA, AGI grade and their combination for poor prognosis. Results: Among the 143 patients, there were 103 cases (72.1%) in the sepsis group and 40 cases (27.9%) in the septic shock group. The number of patients who received continuous renal replacement therapy, surgery, mechanical ventilation, bloody stool, hypoactive bowel sound and procalcitonin concentration in the septic shock group were higher than those in the sepsis group (P<0.05). The red blood cell, hemoglobin and platelet in the septic shock group were lower than those in the sepsis group (P<0.05). Multivariate Logistic regression analysis showed that mechanical ventilation, surgery, decrease of hemoglobin, increase of pSOFA and AGI grade were the independent risk factors for poor prognosis in patients (P < 0.05). ROC curve analysis showed that the predictive value of pSOFA combined with AGI grading for the prognosis of patients was higher than that of them alone (P<0.05) . Conclusion: Mechanical ventilation, surgery, hemoglobin, pSOFA and AGI classification are prognostic factors of sepsis complicated with AGI in children. The pSOFA combined with AGI grade has a high value in predicting the poor prognosis.

  Key words: pediatrics,sepsis, gastrointestinal; disorders, prognosis.

  Submit time: 1 November 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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