Meta-analysis of Risk Factors for Sepsis in Adult Patients with Trauma Wang Bingshenga, Shi Ailib, Wang Binga, Qi Wenhaoa, Zhu Xiaohonga, Dong Chaoquna, Shi Yankaia, Yao Jiania, Lou Xiajinga, Cao Shihu *

Corresponding author: Cao Shihu, caoshihua@126.com

DOI: 10.12201/bmr.202412.00058

•  

  Abstract: 【Abstract】 Objective To conduct a systematic review and analysis of the risk factors linked to sepsis in adult trauma patients, providing evidence-based medical evidence for reducing the incidence of sepsis following trauma. Methods: Literature searches were conducted in the total of 9 databases from their inception to December 2023 on factors influencing sepsis in trauma patients. Meta-analysis was conducted using the meta package in R, and the models heterogeneity was assessed using the I2 value. Results: A total of 10 literatures were included, involving 65,866 adult patients admitted for trauma, with 5,165 cases of sepsis following trauma. The meta-analysis results showed that advanced age (MD=1.31,95%CI:0.51~ 3.12), male gender (OR=1.21, 95%CI: 0.95~1.54), Injury Severity Score (ISS) (MD=5.99, 95%CI: 3.05~8.93), Glasgow Coma Scale (GCS) score (MD=-1.75, 95%CI: -2.68~-0.81), Acute Physiology and Chronic Health Evaluation (APACHE II) score (MD=4.37, 95%CI: 2.56, 6.17), Sequential Organ Failure Assessment (SOFA) score (MD=2.51, 95%CI: 2.30~2.73), mechanical ventilation (OR=4.71, 95%CI: 3.44, 6.45), blood transfusion (OR=2.20, 95%CI: 1.63~2.96), central venous catheterization (OR=2.74, 95%CI: 1.93~3.89), concurrent shock (OR=2.30, 95%CI: 1.70~3.10), and emergency surgery within 24 hours (OR=2.85, 95%CI: 2.00~ 4.07), were identified as independent risk factors for sepsis among trauma patients. Conclusion: Sepsis in trauma patients is influenced by a variety of risk factors,. Clinical medical staff should intervene early in High-risk patients with these factors should be targeted to reduce sepsis incidence among trauma patients.

  Key words: Trauma; Sepsis; Risk Factors; Meta-analysis

  Submit time: 24 December 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
• html

• 图表

• wangshuyao, hilizi, kanghua. Meta-analysis of factors influencing loneliness in older adults. 2024. doi: 10.12201/bmr.202409.00004

  wangguorong, shiwentin, liqinglu. A Systematic review and Meta-analysis of factors influencing skin pruritus in maintenance hemodialysis patients. 2024. doi: 10.12201/bmr.202410.00043

  Chuxin, HeYan, LiNana. Influencing factors of foot self-care behavior in diabetic patients: a Meta-analysis. 2024. doi: 10.12201/bmr.202408.00046

  Analysis of risk factors for hypoglycemia in elderly outpatients with type 2 diabetes. 2024. doi: 10.12201/bmr.202412.00069

  Chen Yuan, Chen Shiqi, Zhang Rongxiang, Zhu Chenyang. Meta-analysis of the effects of ERAS in the perioperative period in patients with heart valve disease. 2024. doi: 10.12201/bmr.202410.00008

  zhang lijuan, zhengyulan, Tianchen, Gelong, qiang qun. Meta-analysis of the diagnostic value of ultrasound and MRI in knee osteoarthritis. 2024. doi: 10.12201/bmr.202412.00072

  钱新阳, wangyumin. Prognostic Value of pSOFA Score Combined with AGI Grade in Children with Sepsis. 2024. doi: 10.12201/bmr.202411.00002

  lu lan mo, yang yi, liu meng lian, wang jun. Net Meta-analysis of the Effect of Intramuscular Patch on Upper Extremity Function and Activities of Daily Living in Stroke Patients. 2024. doi: 10.12201/bmr.202410.00073

  sunjinhuan, wuxiaofei, zhangyuanyuan, guboyu, guofulin. Meta-analysis of Comparison between the Effects of Fenestration and Curettage on Jaw Cyst.. 2024. doi: 10.12201/bmr.202408.00021

  GU Yanhong. Study and evaluation of diagnostic methods for HIV co-infection with tuberculosis: a network meta-analysis. 2024. doi: 10.12201/bmr.202411.00005

• ID	Submit time	Number	Download
  1	2024-10-24	bmr.202412.00058V1	Download

• Public  Anonymous  To author only Submit Comments