The cardiovascular effects of irisin in the rostral ventrolateral medulla of septic rats

Corresponding author: Chai Chen, chaich@lzu.edu.cn

DOI: 10.12201/bmr.202011.00002

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  Abstract: [Objective]To study the cardiovascular effects of irisin within the rostral ventrolateral medulla (RVLM) in sepsis rats. [Methods] The expression of irisin in the RVLM of septic rats was detected by immunohistochemistry. The blood pressure (BP) and heart rate (HR) were recorded by the signal recording analyzer after the different consentration irisin have been micro-injected in RVLM of septic rats. [Results]The expression of irisin in the RVLM of septic rats was significantly decreased (P<0.05). Unilateral microinjection of irisin into the RVLM significantly incrceased BP and HR of septic rats (P<0.05).The cardiovascular effects were changed by the different consentration irisin. [Limitations] The groups and experimental rats are fewer. [Conclusion] The expression of irisin in the RVLM of septic rats is probably involved in the pathological process of sepsis.

  Key words: irisin; sepsis; rostral ventrolateral medulla (RVLM); blood pressure (BP); heart rate (HR)

  Submit time: 17 November 2020

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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