Ｒeview of researches on Nrf2 in oxidative stress-induced atherosclerosis

Corresponding author: WANG Weiwei, 15887299737@163.com

DOI: 10.12201/bmr.202503.00016

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  Abstract: Atherosclerosis is a chronic inflammatory disease that mainly affects the middle and large arteries, which constitutes an important pathological basis for the pathogenesis of cardiovascular diseases. Oxidative stress plays a role in promoting the development of atherosclerosis in many aspects, such as endothelial dysfunction, intimal lipid deposition, inflammation and vascular smooth muscle cell proliferation. Nu-clear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor with anti-oxidative stress, which is involved in the regulation of cellular inflammatory response and lipid metabolism, and is closely related to endothelial cell injury and foam cell formation. It has a dual regulatory effect on atherosclerosis. This review provides an in-depth analysis of the role of Nrf2 in oxidative stress-induced atherosclerosis.

  Key words: ; ; 

  Submit time: 6 March 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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