Research progress on the role of endoplasmic reticulum stress in atherosclerosis based on triple energizer theory

Corresponding author: WU Jianguang, wjgnc@sina.com

DOI: 10.12201/bmr.202501.00011

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  Abstract: Atherosclerosis (AS) is the pathological basis of cardiovascular and cerebrovascular diseases 1, and its related diseases include ischemic heart disease, peripheral artery disease, etc. 2. Chen 3 and others found that the global incidence rate of AS related diseases showed an overall upward trend. The occurrence of atherosclerosis is mainly caused by the accumulation of lipids in large arteries, gradually leading to plaque enlargement, necrotic core formation, and plaque calcification 4. In recent years, a large number of studies have found 5 that endoplasmic reticulum stress (ERS) plays a role in the progression of arterial plaque vulnerability and the occurrence of acute complications of coronary atherosclerosis. Long term activation of cells by ERS in AS lesions may lead to the expression of pro AS factors in advanced AS lesions 6. Regulating ERS can alleviate AS lesions and plaque vulnerability, which is a key target for the prevention and treatment of AS and a current research hotspot. Traditional Chinese Medicine believes that AS belongs to the categories of palpitations and pulse obstruction, and the key pathogenesis is obstruction of the three burners and blockage of the blood vessels by phlegm and blood stasis. Sanjiao is a waterway that mainly flows vital energy and unclogs the waterway. If Sanjiao is blocked, the waterway will lose its flow and operation, leading to the accumulation of yin and pathogenic factors such as phlegm, dampness, blood stasis, etc., which can block the qi flow and blood vessels for a long time, ultimately leading to the occurrence of atherosclerosis. Combining traditional Chinese medicine theory with modern cell biology and molecular biology in recent years, there is a high correlation between the structure and physiological function of the triple junction and endoplasmic reticulum (ER). Therefore, based on the Three Jiao theory and ERS, this article discusses the pathological mechanism of AS from the perspective of traditional Chinese and Western medicine, in order to provide a new perspective for the prevention and treatment of AS.

  Key words: Atherosclerosis; Three Jiao theory; Endoplasmic reticulum stress; Traditional Chinese Medicine; Pathogenesis; Treat

  Submit time: 4 January 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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