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Corresponding author: zhaofenqin, zfqlzh@163.com

DOI: 10.12201/bmr.202501.00040

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  Abstract: Ovarian fibrosis is one of the main causes of ovarian dysfunction and is characterized by excessive proliferation of ovarian fibroblasts and accumulation of extracellular matrix (ECM). As a late manifestation of ovarian injury, the research on the therapeutic targets of ovarian fibrosis is more limited to animal experiments, and there are no effective methods and drugs for anti-ovarian fibrosis in clinical practice. Therefore, it is of great significance to study the pathogenesis and treatment progress of ovarian fibrosis. This article reviews the recent research on the molecular mechanism of ovarian fibrosis from the aspects of promoting fibrosis and inhibiting fibrosis, and summarizes the relationship between ovarian diseases and fibrosis and the current treatment methods for ovarian fibrosis. It provides a theoretical basis for the research and development of new drugs for the treatment of ovarian fibrosis.

  Key words: ovarian fibrosis; extracellular matrix; transforming growth factor β; Research Progress

  Submit time: 15 January 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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