Macrophage Polarization Affects Chronic Kidney Disease:Based on Theory of “Harmful Hyperactivity and Responding Inhibition”

Corresponding author: Cai Xudong, 3148004878@qq.com

DOI: 10.12201/bmr.202407.00027

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  Abstract: Renal fibrosis serves as the primary pathological foundation of chronic kidney disease, with the inflammatory response playing a crucial role in its progression. Macrophages, key regulatory cells in the inflammatory response, exhibit heterogeneity and plasticity, allowing them to polarize into various phenotypes based on the organisms microenvironmental changes, thereby contributing to the development of renal fibrosis in chronic kidney disease. The theory of harmful hyperactivity and responding inhibition is a fundamental concept in traditional Chinese medicine that plays a crucial role in understanding the progression and regression of diseases, as well as guiding their diagnosis and treatment. The correlation between macrophage polarization in chronic kidney disease and the concept of uncontrolled hyperactivity causing harm aligns closely with this theory. The author seeks to elucidate the significance of macrophage polarization in the progression of renal fibrosis by examining theoretical connotations, pathogenesis in Western medicine, pathogenesis in traditional Chinese medicine, and the integration of traditional Chinese and Western medical approaches. Additionally, the author proposes the method of bearing and restraining, leveling hyperactivity, and eliminating harmful effects for the management of chronic kidney disease. The treatment was implemented to strengthen the spleen and kidney in order to enhance the essence, address the underlying issue, and promote overall health; complemented by actions such as resolving phlegm, eliminating dampness, improving blood circulation, removing blood stasis, dispelling turbidity, detoxifying toxins, and calming hyperactivity to mitigate harm. his study aims to enhance the inflammatory response of the kidney by modulating macrophage polarization, offering valuable insights for clinical research. Additionally, it proposes a novel approach for preventing and treating chronic kidney disease by integrating traditional Chinese and Western medicinal practices.

  Key words: harmful hyperactivity and responding inhibition; macrophage polarization; inflammatory response; chronic kidney disease; renal fibrosis; homeostasis of the internal environment; interaction of generation, restriction, control, and transformation

  Submit time: 14 July 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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