许峻川, 费琦. BFH-OST和OSTA对于绝经后妇女骨质疏松风险预测的对比性研究. 2024. biomedRxiv.202407.00019
BFH-OST和OSTA对于绝经后妇女骨质疏松风险预测的对比性研究
通讯作者: 费琦, spinefei@126.com
DOI:10.12201/bmr.202407.00019
A Comparative Study of BFH-OST and OSTA for the Risk Prediction of Osteoporosis in Postmenopausal Women
Corresponding author: fei qi, spinefei@126.com
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摘要:目的:比较新型的北京友谊医院绝经后妇女骨质疏松筛查工具(BFH-OST)和亚洲人骨质疏松自我筛查工具(OSTA)对于绝经后妇女骨质疏松风险的预测作用。方法:随机纳入115例符合标准的北京绝经后骨质疏松妇女,以双能X射线吸收法(DXA)为诊断标准,通过对比BFH-OST、OSTA的ROC曲线,分析两者的诊断效能、曲线差异性。结果: BFH-OST和OSTA均与DXA诊断骨质疏松存在明显相关性(P<0.01), BFH-OST的ROC曲线下面积AUC值0.819,ROC曲线截断值为≤12.2灵敏度为81.25%,特异度为75.90%;OSTA的ROC曲线下面积AUC值0.809,截断值为≤-1.2,灵敏度为81.25%,特异度为72.29%。BFH-OST的ROC曲线和OSTA的ROC曲线存在明显差异,P=0.02<0.05。结论:BFH-OST和OSTA对于绝经后妇女骨质疏松风险均有预测作用,BFH-OST对于绝经后妇女骨质疏松预测诊断效能优于OSTA。
Abstract: Objective: To compare the predictive effect of the new Beijing Friendship Hospital Osteoporosis Self-Assessment Tool (BFH-OST) and Osteoporosis self-assessment tool for Asians (OSTA). Methods: A total of 115 postmenopausal women with osteoporosis in Beijing who met the criteria were randomly enrolled, and dualenergy X-ray absorptiometr (DXA) was used as the diagnostic criterion. The ROC curves of BFH-OST and OSTA were compared to analyze the diagnostic efficacy and differences between the two groups. Results: BFH-OST and OSTA were significantly correlated with DXA in the diagnosis of osteoporosis (P<0.01), the AUC of BFH-OST was 0.819, the cut-off value of the ROC curve was ≤12.2, the sensitivity was 81.25%, and the specificity was 75.90%. The AUC of OSTA was 0.809, the cut-off value was ≤-1.2, the sensitivity was 81.25%, and the specificity was 72.29%. There was a significant difference between the ROC curves of BFH-OST and OSTA (P=0.02<0.05). Conclusion: BFH-OST and OSTA have predictive effects on the risk of osteoporosis in postmenopausal women. BFH-OST is better than OSTA in predicting and diagnosing osteoporosis in postmenopausal women.
Key words: postmenopausal osteoporosis; osteoporosis screening tools; bone mineral density; sensitivity; specificity提交时间:2024-07-11
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序号 提交日期 编号 操作 1 2024-06-12 bmr.202407.00019V1
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