Research Progress on Assessment of Intra-plaque Neovascularization by Superb Microvascular Imaging Technology and Its Relationship with the Expression of CD147 and CD34

Corresponding author: Wang Fanbo, wfanbo@jmsu.edu.cn

DOI: 10.12201/bmr.202509.00022

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  Abstract: The abnormal formation of intraplaque neovascularization (IPN) in atherosclerosis (AS) is a key pathological feature of plaque instability. Superb microvascular imaging (SMI) technology provides an accurate tool for non-invasive assessment of IPN through a scoring system based on the quantity of IPN. This article systematically integrates the principles and clinical value of SMI technology, and meanwhile conducts an in-depth analysis of the molecular associations between IPN and the inflammatory factor CD147 (which mediates inflammation and matrix degradation) as well as the angiogenesis marker CD34 (which reflects angiogenic activity). It also explores the synergistic effect of SMI scores combined with biomarkers in the assessment of plaque stability, ultimately providing a theoretical basis for early risk stratification and precision intervention in AS.

  Key words: Superb Microvascular Imaging Technology; atherosclerotic plaque; neovascularization; SMI score; CD147; CD34

  Submit time: 8 September 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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