Analysis of 237 cases of thyroid related adverse reactions induced by lithium carbonate

Corresponding author: liu yong li, liuyongli2008@126.com

DOI: 10.12201/bmr.202503.00087

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  Abstract: Abstract Objective Investigate the regularity and characteristics of lithium carbonate-induced thyroid adverse reactions ( ADR ), to provide reference for clinical rational drug use. Methods The case reports of thyroid ADR caused by lithium carbonate in the National Adverse Drug Reaction Monitoring System were retrieved, and the gender and age of patients, medication reasons, combined medication, dosage and clinical manifestations of thyroid ADR were retrospectively analyzed. Results A total of 237 cases of thyroid ADRs caused by lithium carbonate were reported, the ratio of male to female was 1:1.7, the frequency was higher in the age group of 20 to 29 years, and the proportion of drug use within the range of instruction dosage was 97.8%. According to the statistics of drugs used in combination, the most drugs were drugs for mental disorders, and the time of ADR occurrence was mostly 10 to 30 days after taking the drug. The main clinical manifestations of thyroid ADR were hypothyroidism, goiter and hyperthyroidism. Conclusion Lithium carbonate-induced thyroid ADR mostly occurred at the therapeutic dose, which was related to the patient s gender, age, combined medication and other factors. Clinicians and pharmacists should master the rules and characteristics of thyroid caused by lithium carbonate, timely detect and treat ADR, to provide guarantee for the safety of patients medication.

  Key words: Lithium carbonate; thyroid hormone; hypothyroidism; goiter enlargement; hyperthyroidism; adverse reactions; safety

  Submit time: 31 March 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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