Adverse events associated with immune checkpoint inhibitors: clinical manifestations and mechanisms

Corresponding author: QIAN Yun, qianyun1985@zju.edu.cn

DOI: 10.12201/bmr.202502.00010

•  

  Abstract: Immune checkpoint inhibitors have demonstrated significant efficacy in various malignant tumors by selectively activating the patients own T lymphocytes against cancer cells. However, this activation can also lead to uncontrolled attacks on normal tissues and organs, resulting in immune-related adverse events of varying severity. This article aims to investigate the clinical manifestations and underlying mechanisms of these immune-related adverse reactions.

  Key words: Immune-related adverse events; Immune checkpoint inhibitors; Tumors; Immunotherapy

  Submit time: 10 February 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
• html

• 图表

• Li Ying, Wang Xiaofei, Lu Shengwei, Dong Danni, Zhang Jingfeng, Zheng Jianjun. CT Findings and Clinical Features of checkpoint Inhibitor-related pneumonitis. 2024. doi: 10.12201/bmr.202407.00008

  Yadian Lei, Haiyan Wang. The Impact of the Tumor Immune Microenvironment on T Cell Function: Focusing on the Limitations of ICB and Combined Treatment Strategies. 2024. doi: 10.12201/bmr.202412.00083

  JIA Bei, DAI Yuanyuan. Sintilimab-induced Diabetes Ketoacidosis with multiple organ immune related adverse reactions:A Clinical Case. 2024. doi: 10.12201/bmr.202411.00022

  Clinical research progress of PD-1/PD-L1 inhibitor induction therapy in unresectable stage III non-small-cell lung cancer. 2025. doi: 10.12201/bmr.202501.00025

  gaoweiwei, lijialin, liudaijian, wangyulin. Correlational Analysis of Immune-Inflammatory Markers with the Clinical Outcomes of Severe Pneumonia. 2024. doi: 10.12201/bmr.202409.00062

  Bao Kaiwen. Research progress on DNA damage and immune response in autoimmune diseases. 2024. doi: 10.12201/bmr.202410.00007

  liuyaru, shihao, sunguanqun, dongjingjing, yehanfeng, zhengleyi, sundan. Design and Research of Intelligent Remote Management System for Tumor Patients after Immunotherapy. 2022. doi: 10.12201/bmr.202206.00007

  WANG Guangyan, NAN Shuang. Mendelian Randomization Study on Cervical Cancer and Immune Cell Phenotypes. 2024. doi: 10.12201/bmr.202412.00050

  ZHONG Xiaoying. The effect of the proportion of atypical lymphocytes on the immune system of children with infectious mononucleosis. 2024. doi: 10.12201/bmr.202410.00032

  Chen Lili. Study on the immune regulatory mechanism of ω－3PUFA in premature infants with brain injury. 2024. doi: 10.12201/bmr.202408.00011

• ID	Submit time	Number	Download
  1	2025-01-09	bmr.202502.00010V1	Download

• Public  Anonymous  To author only Submit Comments