CT Findings and Clinical Features of checkpoint Inhibitor-related pneumonitis

Corresponding author: Zheng Jianjun, zhjjnb2@163.com

DOI: 10.12201/bmr.202407.00008

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  Abstract: Objective：To explore the CT manifestations and clinical features of checkpoint Inhibitor-related pneumonitis (CIP). Methods: Chest CT images and clinical data of 34 patients with CIP in our hospital were collected to retrospectively analyzed , as well as comparing the differences between lung cancer and other types of cancer patients. Results: Cough (70.59%) and dyspnea (52.94%) were the most common clinical symptoms, and the median time to onset of CIP was 130.5d (54.750,231.250), and it occurred earlier and over a greater time span in the lung cancer group (114.5d, 41.50,281.50) than in the other types of cancer group (144d, 55.75,226.25). Eosinophil count was significantly higher only in the other types of cancer group (p=0.009). After hormonal therapy 18 patients improved, 8 were stable and 8 progressed or even died. CT signs were prevalent in ground glass shadow (70.59%) and solid shadow (76.47%), and the imaging pattern was dominated by organic pneumonia (OP) pattern (16 cases, 47.6%), which was not related to the type of primary tumor, and some of them could show nodular granulomatous reaction.Compared to the lung cancer group, the other types of cancer group was more likely to exhibit symmetrical infiltration (58.33%) distribution . Conclusion: The clinical features of CIP are nonspecific,but CIP was different in eosinophil count and chest CT findings between lung cancer and patients with other malignancies

  Key words: Immune Checkpoint Inhibitors; Pneumonia; Multidetector Computed Tomography

  Submit time: 15 August 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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