The Impact of the Tumor Immune Microenvironment on T Cell Function: Focusing on the Limitations of ICB and Combined Treatment Strategies

Corresponding author: Haiyan Wang, wanghaiyan@qhu.edu.cn

DOI: 10.12201/bmr.202412.00083

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  Abstract: ICB, as a rapidly emerging new immunotherapy treatment in recent years, has achieved lasting responses in many patients, but there are still some patients who do not respond to treatment and even experience immune-related adverse events. The poor efficacy of immune checkpoint blockade (ICB) may be related to the impact of the tumor immune microenvironment (TME) on T cell function. We explored various types of T cells, including CD4+ T cells, regulatory T cells (Treg), CD8+ T cells, tissue-resident memory T cells (TRM), and follicular helper T cells (TFH), as well as how they affect the effectiveness of ICB. In addition, this article discusses the limitations of ICB, including low efficacy and immune-related adverse events (irAEs), and explores combined treatment strategies and new methods to improve the TME. Finally, by exploring future research directions, there is hope to enhance the efficacy of ICB and reduce toxicity.

  Key words: Immune Checkpoint Blockade; Immune-related adverse events; Tumor immune microenvironment; T cell

  Submit time: 6 January 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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