The relationship between hyperactivity behavior in children with attention deficit hyperactivity disorder and serum levels of thyroid-stimulating hormone

DOI: 10.12201/bmr.202411.00024

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  Abstract: Objective Exploring the relationship between thyroid function and hyperactive behavior (HB) in children with attention deficit hyperactivity disorder (ADHD), further understanding the potential factors contributing to increased risk of ADHD, and providing references for the treatment of ADHD in children. Methods A total of 134 children with ADHD who met the study criteria were enrolled as subjects and divided into non-HB group and HB group. General information and routine laboratory parameters were compared between the two groups using one-way analysis. HB-related factors were evaluated using binary logistic regression analysis. Finally, Pearson linear correlation analysis and receiver operating characteristic (ROC) curve were used to study the relationship between HB and serum thyrotropin (TSH) and the potential diagnostic value of TSH levels in distinguishing ADHD children with HB. Results The differences in Lac (P=0.040) and TSH (P<0.001) levels between the two groups of cases are statistically significant, with the HB group showing significantly higher levels compared to the non-HB group. Among them, TSH levels are independently associated with HB and positively correlated with the Hyperactivity Index (HI) score (r=0.668, P<0.001). Additionally, TSH levels have a certain value in distinguishing ADHD children with HB, with a cut-off point of 2.57 μIU/ml (sensitivity 65.1%, specificity 74.7%). Conclusion This study revealed a positive correlation between serum TSH levels and HB in children with ADHD, and it can be used to differentiate ADHD children with hyperactivity behavior.

  Key words: Attention Deficit Hyperactivity Disorder; Hyperactivity Index; Thyroid Stimulating Hormone

  Submit time: 11 November 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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