Clinical Research Progress of Gastrin in Gastric Precancerous Lesion

Corresponding author: haoxiaoying

DOI: 10.12201/bmr.202502.00030

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  Abstract: Gastric Precancerous Lesion (GPL) is a necessary stage in the development of gastric cancer (GC), and early screening of GPL can effectively reduce the morbidity and mortality of GC. At present, early screening of GPL can rely on serum tumour markers, such as pepsinogen I/II (PG I/II), glycoantigen 72-4 (CA72-4), glycoantigen 19-9 (CA19-9), glycoantigen 24-2 (CA24-2), glycoantigen 50 (CA50), and gastrin 17 (G-17), and so on, which can reflect gastric mucosal lesions and death rates by detecting the levels of serum tumour markers. The level of serum tumour markers reflects the degree of gastric mucosal lesions and early diagnosis and treatment. Among them, gastrin 17 (G-17) has the highest specificity in GPL screening, and it is found that G-17 can reflect the secretion status and atrophy degree of gastric mucosa in different parts of the stomach, and its serum level decreases with the aggravation of atrophy degree. Therefore, this paper uses “Gastrin, Stomach Neoplasms, Precancerous Conditions, Clinical Studies” as the English Keywords, and “Gastrin, Gastric Cancer, Gastric Precancerous Conditions, Clinical Studies” as the Chinese Keywords to search PubMed and China Knowledge Network (CKN) for the relevant literature in the past 5 years. We discuss the value of G-17 in screening for GPL and provide more references for clinical screening of GPL.

  Key words: Gastrin; Gastric precancerous lesions; Clinical studies; Review

  Submit time: 18 February 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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