Research Progress of Exosomes in Radiation - induced Intestinal InjuryRadiation-induced

Corresponding author: Han, hanxiaopeng74@163.com

DOI: 10.12201/bmr.202501.00026

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  Abstract: Radiation - induced intestinal injury (RII) is a common side - effect of radiotherapy that severely impacts the quality of life of patients. In recent years, exosomes, as a novel medium for intercellular communication, have been found to promote the proliferation and regeneration of intestinal mucosal cells, inhibit the inflammatory response and fibrotic process, and repair the damaged intestinal epithelial barrier. Currently, there are no relevant reports on the direct application of exosomes in RII. This article reviews the therapeutic potential of exosomes in RII at home and abroad in recent years, aiming to provide new research directions for the treatment of RII and offer new ideas for the development of exosome - based therapeutic drugs for RII and their translation into clinical applications.

  Key words: Radiation; Intestinal injury; Exosomes; Mechanism of action

  Submit time: 16 January 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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