Research progress of red blood cell storage lesion

DOI: 10.12201/bmr.202502.00021

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  Abstract: Quality Control Department, Tianjin Blood Center, Tianjin.Abstract: Transfusion of red blood cells (RBCs) saves lives. RBCs have evolved to optimally supply oxygen by packing high concentrations of haemoglobin in their cytosol and shedding nuclei and other organelles. Stored RBCs undergo a series of biochemical, morphological and functional changes. These modifications-collectively referred to as “storage lesion(s)”. In recent years, with the development of omics and other technologies, the mechanism of red blood cell storage lesion, measures to improve the storage quality and clinical consequences have been the research hotspots in this field. This paper reviews the above contents based on the current research of storage lesion.

  Key words: Red blood cells; storage lesion; Transfusion; blood storage

  Submit time: 13 February 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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  1	2025-02-05	bmr.202502.00021V1	Download

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