Research progress and prospect of targeted therapy of microflora in hepatocellular carcinoma

Corresponding author: weiyunwei, hydwywll@hotmail.com

DOI: 10.12201/bmr.202412.00033

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  Abstract: Microorganisms, including bacteria, viruses, fungi and other eukaryotes, play a vital role in human health. Over the past few decades, great progress has been made in understanding how the microbiome interacts with cancer. However, most research has focused on the gut microbiome and ignored how other microbiome interact with tumors. In recent years, the study of intratumoral microorganisms (referred to as intratumoral microbiota) and cancer has received extensive attention. More and more studies have shown that intratumoral microbiota are closely related to the pathophysiological process of liver cancer. Intratumoral microbiota not only affect immune regulation, but also may accelerate the progression of liver cancer by participating in inflammatory response, metabolic regulation and other mechanisms. However, to fully understand the role of the intratumoral microbiome, further study of its role and mechanism is still needed. This paper focuses on the discovery, origin and distribution characteristics of microbiota in hepatoma, especially the potential mechanism of action in the occurrence and development of hepatoma. This paper also further analyzed the potential of intratumoral microorganisms in the early diagnosis of liver cancer, treatment response prediction and personalized treatment, especially its application prospect in targeted therapy, providing a new idea and direction for microbial intervention in precision medicine in the future.

  Key words: Liver cancer; Intratumoral microbiota; Tumor microenvironment; Therapy

  Submit time: 6 January 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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