Association Between Gut Microbiota and Liver Cirrhosis in East Asian Populations: A Mendelian Randomization Study

Corresponding author: zhang tao, 9087958@qq.com

DOI: 10.12201/bmr.202412.00049

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  Abstract: Abstract: Objective: This study aims to explore the association between gut microbiota and liver cirrhosis in East Asian populations using Mendelian Randomization (MR) methods. Methods: To obtain the genome-wide association study (GWAS) datasets on gut microbiota from the National GeneBank Big Data Platform and the GWAS datasets on liver cirrhosis from the IEU Open GWAS database, using gut microbiota as the exposure factor and liver cirrhosis as the outcome variable. The main analytical method adopted is the inverse variance weighted (IVW) method, with the constrained maximum likelihood and model averaging (cML-MA) method as a secondary analysis method, to verify the causal relationship between gut microbiota and liver cirrhosis. The robustness of the results will be further validated through sensitivity analysis and leave-one-out analysis. Results: The primary IVW analysis preliminarily identified 16 gut microbiota species associated with liver cirrhosis. An increased abundance of Marvinbryantia, Desulfovibrio, Coprococcus, Treponema socranskii, Ruminococcaceae, Sanguinibacter, Vibrio furnissii, Clostridium L2-50, Thermanaerovibrio, and Mitsuokella was found to elevate the risk of liver cirrhosis. Conversely, an increased abundance of Desulfovibrio, Clostridium hathewayi, Propionibacterium, Allistipes, Bacteroides salanitiphilus, and Dyella was associated with a reduced risk of liver cirrhosis. The cML-MA analysis revealed statistical significance for Mitsuokella, Clostridium L2-50, Marvinbryantia, Coprococcus, and Dyella, indicating a strong correlation between these five gut microbiota species and liver cirrhosis. The heterogeneity and horizontal pleiotropy for 16 bacterial clusters showed P > 0.05, suggesting an absence of heterogeneity and horizontal pleiotropy, and the leave-one-out analysis did not identify any outlier SNPs. Conclusion: This research reveals an association between 16 gut microbiota and liver cirrhosis in the East Asian population, with 5 of these gut microbiota demonstrating a significant correlation with liver cirrhosis, offering new genetic insights for the prevention and treatment of liver cirrhosis.

  Key words: Mendelian randomization; East Asian population; gut microbiota; liver cirrhosis; genome-wide association study

  Submit time: 20 December 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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