Efficacy and safety of Zhangs Qingre Xiaoyu Decoction combined with VSD in the treatment of open tibia and fibula fracture wound infection

Corresponding author: fengqi, lsq112233l@163.com

DOI: 10.12201/bmr.202410.00023

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  Abstract: Objective To study the efficacy and safety of Zhangs Qingre Xiaoyu Decoction combined with VSD in the treatment of infected wounds of open tibia and fibula fractures. Methods The random number table method was used to divide 70 patients with open tibia and fibula fracture infection who were1 diagnosed and treated from January 2022 to January 2024 into the control group (VSD treatment) and the observation group (Zhangs Qingre Xiaoyu Decoction combined with VSD treatment). , compare the differences in fibroblast morphology, proliferation ability, efficacy, complications, inflammatory factors, T lymphocytes, CD64, CRP, Alb, and fibrillar collagen between the two groups of patients. Results The observed fibroblast morphology and proliferation ability were better than those in the control group. The wound healing rate and wound granulation tissue growth score of patients with tibiofibular fracture infection in the observation group after treatment were significantly higher than those of the control group (P<0.05). The positive rate of etiology, the disappearance time of calf swelling, and the VAS score were all significantly lower than those of the control group. group of patients (P<0.05). There were no statistically significant differences in the incidence of gastrointestinal reactions, liver and kidney function damage, local dermatitis, and deep vein thrombosis between the observation group and the control group (P>0.05). PCT, TNF-α, IL-1β, IL-6, IL-8, CD3+, CD4+, CD8+, CD64, CRP, Alb, CRP/Alb, COL Ⅰ, COL Ⅲ, COL Ⅴ before treatment in the observation group and control group There was no statistical difference (P>0.05) between PCT, TNF-α, IL-1β, IL-6, IL-8, CD3+, CD8+, CD64, CRP, Alb, and CRP/Alb after treatment. were significantly lower than those before treatment (all P<0.05), and CD4+, COL Ⅰ, COL Ⅲ, COL Ⅴ and COL Ⅺ were significantly higher than those before treatment (all P<0.05). After treatment, the PCT, TNF-α, IL-1β, IL-6, IL-8, CD3+, CD8+, CD64, CRP, Alb, and CRP/Alb of the patients in the observation group were significantly lower than those of the patients in the control group (all P<0.05). , CD4+, COL Ⅰ, COL Ⅲ, COL Ⅴ and COL Ⅺ were significantly higher than those in the control group (all P<0.05). Conclusion Zhangs Qingre Xiaoyu Decoction combined with VSD can significantly promote fibroblast proliferation and fibrous collagen synthesis and reduce inflammatory response in the treatment of infected wounds of open tibia and fibula fractures. Its efficacy and safety are better than traditional VSD treatment.

  Key words: open tibia and fibula fractures; infected wounds; Zhangs Qingre Xiaoyu Decoction; VSD; efficacy; safety

  Submit time: 10 October 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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