• 国家药监局综合司 国家卫生健康委办公厅
  • 国家药监局综合司 国家卫生健康委办公厅

Analysis of the Curative Effect of Combined Treatment of Renal or Upper Ureteral Calculi with Double Endoscopy

Corresponding author: HUANG Yongping, h.y.p.1968@163.com
DOI: 10.12201/bmr.202408.00067
Statement: This article is a preprint and has not been peer-reviewed. It reports new research that has yet to be evaluated and so should not be used to guide clinical practice.
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    Abstract: Objective: To investigate the efficacy of negative pressure combined ureteroscopy ( Wo Tong mirror ) combined with flexible ureteroscopy holmium laser lithotripsy in the treatment of renal or upper ureteral calculi with a maximum diameter of 2 ~ 4cm. Methods: The data of patients with renal or upper ureteral calculi with a maximum diameter of 2 ~ 4cm who were hospitalized in our hospital from March 2023 to March 2024 were collected and divided into observation group and control group. The observation group was treated with negative pressure combined ureteroscopy ( Wo Tong Mirror ) combined with flexible ureteroscopy for holmium laser lithotripsy, and the control group was treated with Lisson nephroscope for percutaneous nephrolithotomy (PCNL). The operation time, postoperative hospital stay, changes of blood routine white blood cell (WBC) before and after operation, changes of urine routine WBC before and after operation, postoperative visual analogue pain score (VAS), one-stage stone clearance rate and postoperative complications were compared between the two groups. Results: The postoperative hospitalization time and visual analogue pain score (VAS) of the observation group were significantly lower than those of the control group (p<0.05). There was no significant difference in the operation time, stone clearance rate, postoperative blood routine WBC and postoperative urine routine WBC between the two groups (p>0.05). However, the blood routine WBC of the two groups after operation was higher than that before operation (p<0.05).The overall stone clearance rate of the two surgical methods was 86.25 %, of which the stone clearance rate of the observation group was 82.5 %, and the control group was 90 %. There was no significant difference between the two groups (p>0.05).Conclusion: It is safe and effective to treat renal or upper ureteral calculi with a maximum diameter of 2 ~ 4cm by Wharton s mirror combined with flexible ureteroscope holmium laser lithotripsy. It is expected to partially replace PCNL and become another safe and reliable operation for the treatment of renal or upper ureteral calculi with a maximum diameter of 2 ~ 4cm.

    Key words: Negative pressure combined ureteroscope; Flexible ureteroscope; renal and upper ureteral calculi; Holmium laser lithotripsy

    Submit time: 27 August 2024

    Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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    1 2024-07-24

    bmr.202408.00067V1

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NONG Guangren, LI Honghai, LU Baode, HUANG Yongping. Analysis of the Curative Effect of Combined Treatment of Renal or Upper Ureteral Calculi with Double Endoscopy. 2024. biomedRxiv.202408.00067

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