Analysis of the efficacy and influencing factors of radiotherapy after keloid surgery

Corresponding author: Li Minjie, liminjie0326@sina.com

DOI: 10.12201/bmr.202410.00014

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  Abstract: Objective　To explore the efficacy of hypofractionated radiotherapy at different time intervals after surgery for keloid, and to analyze the factors affecting the efficacy. Methods　A retrospective analysis was conducted on the clinical data of 76 patients who received 20Gy/5 fractions of radiotherapy from January 2021 to June 2023. Regularly follow up and record the patients’ treatment outcome and occurrence of adverse reactions after radiotherapy. Univariate analysis and multivariate logistic regression analysis were performed to analyze the factors affecting the efficacy of patients with keloid treatment. Results　The recurrence rate of keloids after radiotherapy was 21% and no secondary malignancies occurred.. Based on recurrence status,keloids were categorized into an effective group (79 cases) and a recurrent group (21 cases). Univariate analysis revealed statistically significant differences in family history (χ2=4.571, P=0.033), keloid location (χ2=8.012, P=0.018), keloid incision size (χ2=4.002, P=0.045), and time to postoperative radiotherapy (χ2=6.944, P=0.031). Multivariate Logistic regression analysis showed that postoperative radiotherapy time and keloid incision size were associated with post-treatment recurrence. Radiotherapy within ≤7 hours post-surgery (OR＞1, P=0.022) was an independent risk factor for post-treatment recurrence, while keloid incision size ≤5 cm (OR＜1, P=0.028) was an independent protective factor for post-treatment recurrence. Conclusion　Surgical excision combined with hypofractionated radiotherapy is one of the effective measures to prevent and treat keloid recurrence, though keloids on the trunk may need more effective treatment options. The recurrence rate of radiotherapy initiated 7-48 hours after surgery is relatively the lowest, and it is worthy of clinical promotion and application.

  Key words: ; ; ; 

  Submit time: 8 October 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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